SEX HORMONE-INDUCED NUCLEAR-DNA DAMAGE AND LIPID-PEROXIDATION IN THE DORSOLATERAL PROSTATES OF NOBLE RATS
SEX HORMONE-INDUCED NUCLEAR-DNA DAMAGE AND LIPID-PEROXIDATION IN THE DORSOLATERAL PROSTATES OF NOBLE RATS
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DOI：
10.1016/0304-3835(94)90370-0
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发表时间：
1994-09-15
期刊：
影响因子：
9.7
通讯作者：
ROY, D
中科院分区：
文献类型：
--
作者：
HO, SM;ROY, D
To date, few studies have been reported on any aspect of DNA damage in organs of intact animals. We and others demonstrated induction of high incidences of dysplasia, a precancerous proliferative lesion, and adenocarcinoma selectively in the dorsolateral prostates (DLPs) of Noble rats exposed to a long-term combined testosterone and estradiol-17 beta treatment (T + E(2)-treatment). We here report induction of a significant increase in DNA strand breakage and accumulation of lipid peroxidation fluorescent products in the DLPs, but not in the ventral prostates (VPs), of rats treated with T + E(2) for 16 weeks. These results indicate that this dual hormone treatment has free radical-based DNA damaging effect on rat DLP and therefore may have tumor-initiating action. Since a similar effect was not observed in regenerating DLPs of castrated rats following testosterone replacement, we conclude that the genotoxic effect of the dual hormone treatment is a direct result of hormone action and not secondarily due to enhancement of cell proliferation.
