Challenges and perspectives in quantitative NMR
Challenges and perspectives in quantitative NMR
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DOI：
10.1002/mrc.4475
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发表时间：
2017-01-01
影响因子：
2
通讯作者：
Giraudeau, Patrick
中科院分区：
文献类型：
--
作者：
Giraudeau, Patrick
本文从作者在2016年初的观点出发，总结了定量核磁共振领域的主要挑战和前景。首先概述了定量核磁共振的关键概念，然后讨论了在分辨率和灵敏度方面的最新进展，以及该领域未来的一些可能的研究方向。特别关注能够提高定量核磁共振的分辨率和灵敏度的方法，这可能在样品复杂性和分析物浓度特别具有挑战性的领域打开应用前景。这些技术包括多维定量核磁共振和超极化技术，如对氢诱导极化或动态核极化。由于定量核磁共振不能脱离分析化学的关键概念，即真实性和精密度，因此系统地描述了方法的发展及其分析性能的水平。版权所有(C)2016 John Wiley&Sons，Ltd.
This perspective article summarizes, from the author's point of view at the beginning of 2016, the major challenges and perspectives in the field of quantitative NMR. The key concepts in quantitative NMR are first summarized; then, the most recent evolutions in terms of resolution and sensitivity are discussed, as well as some potential future research directions in this field. A particular focus is made on methodologies capable of boosting the resolution and sensitivity of quantitative NMR, which could open application perspectives in fields where the sample complexity and the analyte concentrations are particularly challenging. These include multi-dimensional quantitative NMR and hyperpolarization techniques such as para-hydrogen-induced polarization or dynamic nuclear polarization. Because quantitative NMR cannot be dissociated from the key concepts of analytical chemistry, i.e. trueness and precision, the methodological developments are systematically described together with their level of analytical performance. Copyright (C) 2016 John Wiley & Sons, Ltd.