Risk factors for gametocyte carriage in uncomplicated falciparum malaria
Risk factors for gametocyte carriage in uncomplicated falciparum malaria
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DOI：
10.4269/ajtmh.1999.60.1019
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发表时间：
1999-06-01
影响因子：
3.3
通讯作者：
White, NJ
中科院分区：
文献类型：
--
作者：
Price, R;Nosten, F;White, NJ
在泰国西部边境的低度季节性传播地区进行了一系列抗疟药物试验，对 5,682 名患者进行了前瞻性评估，对影响恶性疟原虫配子细胞血症发展的因素进行了评估。在 4,565 名入院厚涂片评估患者中，110 名 (2.4%) 患有配子体血症。在随访期间，所有患者中有 170 名 (3%) 出现配子体未闭症，其中 89% 是在治疗后第 14 天出现的。在多元逻辑回归模型中，发现五个因素是随访期间配子体血症发生或持续存在的独立危险因素；入院时配子体未闭（调整后优势比 [AOR] = 7.8，95% 置信区间 [CI] = 3.7-16，P < 0.001）、贫血（血细胞比容
The factors affecting the development of patent Plasmodium falciparum gametocytemia were assessed in 5,682 patients entered prospectively into a series of antimalarial drug trials conducted in an area of low and seasonal transmission on the western border of Thailand. Of the 4,565 patients with admission thick smear assessments, 110 (2.4%) had gametocytemia. During the follow-up period 170 (3%) of all patients developed patent gametocytemia, which in 89% had developed by day 14 following treatment. In a multiple logistic regression model five factors were found to be independent risk factors at presentation for the development or persistence of gametocytemia during follow up; patent gametocytemia on admission (adjusted odds ratio [AOR] = 7.8, 95% confidence interval [CI] = 3.7-16, P < 0.001), anemia (hematocrit