REPRODUCTIVE AND MENSTRUAL FACTORS IN RELATION TO MAMMOGRAPHIC PARENCHYMAL PATTERNS AMONG PERIMENOPAUSAL WOMEN
REPRODUCTIVE AND MENSTRUAL FACTORS IN RELATION TO MAMMOGRAPHIC PARENCHYMAL PATTERNS AMONG PERIMENOPAUSAL WOMEN
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DOI：
10.1038/bjc.1995.128
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发表时间：
1995-03-01
影响因子：
8.8
通讯作者：
TABAR, L
中科院分区：
文献类型：
--
作者：
GRAM, IT;FUNKHOUSER, E;TABAR, L
1986-87 年开展的第三次特罗姆瑟研究对 3640 名年龄 40-56 岁的挪威女性进行了乳房 X 光检查模式与生殖和月经因素之间的关系检查。流行病学数据通过问卷调查获得。乳房X光检查分为五组。这种分类基于解剖学-乳房X线照相相关性，遵循三维（厚切片技术）组织病理学-乳房X线照相比较，而不是简单的图案读取。将模式1-3合并为低风险组，将模式4和5合并为高风险组进行分析。在控制年龄、体重、身高和绝经状态的情况下，生育四个以上孩子的女性出现高危模式的可能性比未生育的女性低 90%（OR = 0.09，95% CI 0.04-0.16）。此外，根据胎次进行调整后，在 34 岁以上首次生育的女性出现高风险模式的可能性是十几岁时生育的女性的两倍多（OR = 2.37，95% CI 1.23-4.56）。在绝经后女性中，初潮年龄与高风险模式呈负相关（趋势 P = 0.015），绝经年龄晚与高风险模式呈正相关（趋势 P = 0.072）。在绝经前女性中，初潮年龄与高风险模式呈正相关（趋势 P = 0.001）。此外，更年期状态而不是年龄与高风险模式相关。这些发现支持这样的观点，即生殖和月经因素参与确定围绝经期妇女的乳房X光检查实质模式。
The relationship between mammographic patterns and reproductive and menstrual factors was examined in 3640 Norwegian women, aged 40-56 years, participating in the Third Tromso study conducted in 1986-87. Epidemiological data were obtained from questionnaires. The mammograms were categorised into five groups. This categorisation is based on anatomic-mammographic correlations, following three-dimensional (thick slice technique) histopathologic-mammographic comparisons, rather than simple pattern reading. Patterns 1-3 were combined into a low-risk group and patterns 4 and 5 into a high-risk group for analysis. Women who had more than four children were 90% less likely to have a high-risk pattern than nulliparous women (OR = 0.09, 95% CI 0.04-0.16) controlling for age, weight, height and menopausal status. Furthermore, those who first gave birth over 34 years of age were more than twice as likely to have a high-risk pattern than those giving birth in their teens (OR = 2.37, 95% CI 1.23-4.56) adjusting for parity. Among post-menopausal women, age at menarche was negatively (P for trend = 0.015) and late age at menopause positively (P for trend = 0.072) related to high-risk patterns. Among premenopausal women, age at menarche was positively related to high-risk patterns (P for trend = 0.001). Also, menopausal status rather than age was associated with high-risk patterns. These findings support the opinion that reproductive and menstrual factors are involved in determining the mammographic parenchymal pattern among perimenopausal women.