STUDIES ON THE CHELATION OF ALUMINUM FOR NEUROBIOLOGICAL APPLICATION
STUDIES ON THE CHELATION OF ALUMINUM FOR NEUROBIOLOGICAL APPLICATION
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DOI：
10.1016/s0162-0134(00)80290-1
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发表时间：
1981-01-01
影响因子：
3.9
通讯作者：
DAVIS, JM
中科院分区：
文献类型：
--
作者：
RAJAN, KS;MAINER, S;DAVIS, JM
在离子强度为0.12 M的条件下，考察了Al(III)与水杨酸(SA)、柠檬酸(CIT)、EDTA、乙二胺-二-(邻羟基苯乙酸)(EDDHA)、N,N''-二-(2-羟基苯甲基)乙二胺-N,N''-二乙酸(HBED)以及由上述配体组成的一些混合配体体系的螯合形成和强度。氯化钠和25.0.+-。 0.1.度。 C. 所考虑的所有配体均与 Al(III) 形成强螯合物。它们的 Al(III) 螯合物的稳定性 (log KML) 顺序为 SA (13.7) < EDTA (15.3) < CIT (18.0) < EDDHA (24.5) .simeq。 HBED (24.8)。 Al(III)-SA (1:1)、Al(III)-CIT (1:1) 和 Al(III)-SA-CIT (1:1:1) 体系的平衡分析表明，它们各自发生了水解和聚合反应。 Al(III)-EDTA (1:1) 螯合物即使在 pH 5 下也会发生水解。EDDHA 和 HBED 各自与 Al(III) 形成非常稳定的单核螯合物，并且没有表现出水解或聚合倾向。微量金属参与神经递质功能，大脑中的微量金属水平可能会影响疾病状态。
The formation and strength of chelation of Al(III)with salicylic acid (SA), citric acid (CIT), EDTA, ethylenediamine-di-(ortho-hydroxyphenylacetic acid) (EDDHA), N,N''-di-(2-hydroxybenzyl)ethylenediamine-N,N''-diacetic acid (HBED) and some mixed ligand systems consisting of the above ligands were examined at an ionic strength of 0.12 M NaCl and 25.0 .+-. 0.1.degree. C. All the ligands under consideration form strong chelates with Al(III). The order of the stabilities (log KML) of their Al(III) chelates are SA (13.7) < EDTA (15.3) < CIT (18.0) < EDDHA (24.5) .simeq. HBED (24.8). An equilibrium analysis of the Al(III)-SA (1:1), Al(III)-CIT (1:1) and Al(III)-SA-CIT (1:1:1) systems indicated the occurrence of hydrolysis and polymerization reactions in each of them. The Al(III)-EDTA (1:1) chelate underwent hydrolysis even at pH 5. EDDHA and HBED each formed a very stable mononuclear chelate with Al(III) and did not show hydrolytic or polymerization tendencies. Trace metals are involved in neurotransmitter function, and trace metal levels in the brain may affect disease state.