Building a Framework for Embryonic Microenvironments and Cancer Stem Cells
Building a Framework for Embryonic Microenvironments and Cancer Stem Cells
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DOI：
10.1007/s12015-009-9096-7
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发表时间：
2009-11
影响因子：
4.8
通讯作者：
A. Ruiz-Vela;C. Aguilar-Gallardo;C. Simón
中科院分区：
文献类型：
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作者：
A. Ruiz-Vela;C. Aguilar-Gallardo;C. Simón
在神经和造血系统中，假定存在由双向基质和干细胞分泌因子组成的癌症干细胞小生境，其触发癌症干细胞生长和增殖。根据这一理论，已经提出胚胎干细胞微环境在与癌症干细胞相互作用时可以重编程癌细胞，导致肿瘤细胞性质的实质性抑制。在这里，我们讨论了支持这种新概念的癌症抑制因子的背景下，胚胎微环境以及胚胎干细胞（ESC）的新兴数据。
The putative existence of a cancer stem cell niche consisting of bi-directional stromal and stem cell secreting factors that trigger cancer stem cell growth and proliferation has been hypothesized in the nervous and hematopoietic systems. In light of this theory, it has been proposed that embryonic stem cell microenvironments, upon interactions with cancer stem cells, may reprogram cancer cells resulting in a substantial inhibition of tumor cell properties. Here, we discuss emerging data that support this novel concept of cancer inhibitory factors produced in the context of embryonic microenvironments as well as by embryonic stem cells (ESCs).