Analysis of prognostic factors and comparison of prognostic scores in peripheral T cell lymphoma, not otherwise specified: a single-institution study of 105 Chinese patients
Analysis of prognostic factors and comparison of prognostic scores in peripheral T cell lymphoma, not otherwise specified: a single-institution study of 105 Chinese patients
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未另有说明的外周T细胞淋巴瘤的预后因素分析和预后评分比较：一项针对105名中国患者的单机构研究
DOI：
10.1007/s00277-014-2188-8
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发表时间：
2015-02-01
影响因子：
3.5
通讯作者：
Zhao, Weili
中科院分区：
文献类型：
--
作者：
Xu, Pengpeng;Yu, Dong;Zhao, Weili
外周T细胞淋巴瘤，未另行说明（PTCL-NOS）是非霍奇金淋巴瘤的异质亚型。本研究旨在更好地定义预后因素，并比较中国PTCL-NOS患者预后评分的预测价值。我们对105例诊断为PTCL-NOS的患者进行了回顾性研究，并根据4种先前描述的预后评分[国际预后指数（IPI），PTCL-NOS预后指数（PIT），改良PIT（m-PIT）和国际PTCL项目（IPTCLP）]进行分组。除临床参数外，外周淋巴细胞减少症和血小板减少症、血清EB病毒阳性和肿瘤Ki-67与疾病预后不良显著相关。多变量分析显示，年龄> 60岁、体力状态差、乳酸脱氢酶升高和骨髓受累是影响生存率的独立不良变量。所有预后评分均成功用于生存估计。IPI和PIT的危险亚组可以分别通过血小板计数（IPTCLP因子）和Ki-67（m-PIT因子）进一步区分。总之，患者和肿瘤特异性特征可纳入PTCL-NOS患者的风险分层。预后评分可以相互作用，以提高其对疾病结局的预测价值。
Peripheral T cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous subtype of non-Hodgkin's lymphoma. This study aims to better define the prognostic factors and compare the predictive value of the prognostic scores in Chinese patients with PTCL-NOS. One hundred and five patients diagnosed as PTCL-NOS from our institution were retrospectively studied and grouped according to four previously described prognostic scores [International Prognostic Index (IPI), Prognostic Index for PTCL-NOS (PIT), modified PIT (m-PIT), and International PTCL Project (IPTCLP)]. In addition to clinical parameters, peripheral lymphopenia and thrombocytopenia, serum Epstein-Barr virus positivity, and tumor Ki-67 were significantly associated with poor disease outcome. Multivariate analysis revealed that age > 60 years, poor performance status, elevated lactic dehydrogenase, and bone marrow involvement were independent adverse variables for survival. All prognostic scores were successful for survival estimation. Risk subgroups in IPI and PIT could be further discriminated by platelet count (IPTCLP factor) and Ki-67 (m-PIT factor), respectively. Together, patient- and tumor-specific characteristics may be incorporated in risk stratification of PTCL-NOS patients. The prognostic scores could be mutually active to improve their predictive value of disease outcome.