Effect on uropathogens of prophylaxis for urinary tract infection in spinal cord injured patients: preliminary study
Effect on uropathogens of prophylaxis for urinary tract infection in spinal cord injured patients: preliminary study
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DOI：
10.1038/sj.sc.3100456
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发表时间：
1997-09-01
期刊：
影响因子：
2.2
通讯作者：
Howard, L
中科院分区：
文献类型：
--
作者：
Reid, G;Howard, L
脊髓损伤患者极易发生尿路感染。高复发率、耐药问题和与诊断相关的困难使治疗变得复杂。在对30例患者档案的初步回顾研究中，我们发现甲氧嘧啶-磺胺甲恶唑预防性抗菌治疗显著降低了症状性尿路感染的发生率。预防感染导致了比治疗更便宜的医疗费用。一个有问题的结果是，抗生素治疗导致感染宿主的尿路病原体种群发生了戏剧性的变化，从以革兰氏阴性为主的类型转变为以粪肠球菌为主的类型。
Spinal cord injured patients are highly prone to urinary tract infections. The high frequency of recurrences, the problems with drug resistance and the difficulties associated with diagnosis complicate the management. In a preliminary retrospective study of 30 patient files, we discovered that prophylactic antimicrobial therapy with trimethoprim-sulfamethoxazole, significantly reduced the incidence of symptomatic urinary tract infections. The prevention of infection resulted in cheaper healthcare expenses than treatment. One problematic outcome was that antibiotic therapy resulted in a dramatic change in the population of uropathogens infecting the host, from a predominantly Gram negative type to one dominated by Enterococcus faecalis.