5-fluorouracil and glaucoma filtering surgery: I. An animal model.
5-fluorouracil and glaucoma filtering surgery: I. An animal model.
复制标题
5-氟尿嘧啶和青光眼滤过手术：I.动物模型。
DOI：
10.1016/s0161-6420(84)34277-4
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发表时间：
1984
期刊：
影响因子：
13.7
通讯作者：
Folberg,R
中科院分区：
文献类型：
--
作者：
Gressel,MG;Parrish2nd,RK;Folberg,R
青光眼滤过手术的失败通常是由于手术部位的疤痕造成的。成纤维细胞在疤痕形成过程中发挥重要作用。 5-氟尿嘧啶是一种抗代谢药，能够抑制成纤维细胞增殖。我们在实验模型中测试了 5-氟尿嘧啶抑制过滤部位疤痕形成的能力。对十只正常猫头鹰猴的每只眼睛进行后唇巩膜切除术。术后，每只动物的一只眼睛接受结膜下注射氟尿嘧啶，另一只眼睛以随机、隐蔽的方式接受盐水注射。两只动物死于不明原因。对照组的眼睛都没有出现水泡，但幸存动物的八只接受治疗的眼睛中有六只出现了水泡。氟尿嘧啶治疗眼与对照眼的眼压差异有统计学意义（P<0.05）。眼部毒性症状包括持续性角膜上皮缺陷和结膜切口愈合延迟。这些结果比之前在非人类灵长类动物中进行的实验过滤程序报道的结果要有利得多。伤口愈合的药物调节可能会降低过滤操作失败的风险。
Failure of a glaucoma filtering procedure commonly results from scarring at the surgical site. Fibroblasts play an important role in the scarring process. 5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation. We tested the ability of 5-fluorouracil to inhibit cicatrization at the filtering site in an experimental model. Posterior lip sclerectomies were performed in each eye of ten normal owl monkeys. Postoperatively, one eye of each animal received subconjunctival injections of fluorouracil and the fellow eye received saline injections in a randomized, masked fashion. Two animals died of undetermined causes. None of the control eyes developed blebs, but six of the eight treated eyes in surviving animals developed blebs. The difference between intraocular pressures in fluorouracil-treated and control eyes was statistically significant (P< 0.05). Signs of ocular toxicity included persistent corneal epithelial defects and delayed healing of the conjunctival incision. These results are considerably more favorable than those previously reported with experimental filtering procedures in non-human primates. Pharmacologic modulation of wound healing may decrease the risk of failure of filtering operations.