ASSESSMENT OF THE LACTULOSE MANNITOL TEST IN CROHNS-DISEASE
ASSESSMENT OF THE LACTULOSE MANNITOL TEST IN CROHNS-DISEASE
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DOI：
10.1136/gut.29.4.511
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发表时间：
1988-04-01
期刊：
影响因子：
24.5
通讯作者：
MINAIRE, Y
中科院分区：
文献类型：
--
作者：
ANDRE, F;ANDRE, C;MINAIRE, Y
对100名健康对照者和47名克罗恩病患者进行甘露醇-乳果糖肠通透性试验。这些患者进一步分为活性增加的三个亚组（Harvey-Bradshaw指数）和选择性结肠病变及相关回肠和结肠病变的两个亚组。结果以尿中甘露醇(M)、乳果糖(L)和L/M比的回收率百分比给出。总体而言，克罗恩病患者的平均M值低于对照组，平均L值和平均L/M值高于对照组。M、L和L/M的变化幅度随着活动的增加而增加。然而，该测试的敏感性仅在由复发患者组成的III亚组中达到了有趣的数字（67%；L和86%；L/M）。伴有相关回肠病变的患者的平均M值较低，但无论采用何种标准（M、L或L/M），该测试都不能提供任何线索，以检测可能的临床外相关回肠定位。
The mannitol-lactulose intestinal permeability test was evaluated in 100 healthy controls and 47 patients with Crohn''s disease. These patients were further separated into three subgroups of increased activity (Harvey-Bradshaw index) and in two subgroups, with elective colonic lesions and associated ileal and colonic lesions. Results were given as percentages of urinary recoveries for mannitol (M), lactulose (L), and L/M ratio. As a whole, patients with Crohn''s disease have lower mean M and higher mean L and mean L/M ratios than controls. The magnitude of alterations in M, L, and L/M increased with activity. The sensitivity of the test, however, reached interesting figures (67%; L and 86%; L/M) only in subgroup III which was composed of relapsing patients. Mean M was lower in patients with associated ileal lesion but, whatever the criterion (M, L or L/M), the test does not provide any clue for the detection of a possible infraclinical associated ileal localisation.