An assessment tool for predicting fracture risk in postmenopausal women
An assessment tool for predicting fracture risk in postmenopausal women
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DOI：
10.1007/s001980170072
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发表时间：
2001-01-01
影响因子：
4
通讯作者：
Johnell, O
中科院分区：
文献类型：
--
作者：
Black, DM;Steinbuch, M;Johnell, O
由于与未经治疗的骨质疏松症相关的发病率和死亡率的幅度，识别高风险个体以便他们能够接受适当的评估和治疗是至关重要的。本研究的目的是开发一种简单的临床评估工具，基于少量的风险因素，可供女性或其临床医生评估其骨折风险。使用来自骨质疏松性骨折研究（SOF）的数据，共有7782名年龄在65岁及以上的女性骨矿物质密度（BMD）测量和基线风险因素被纳入分析。通过识别在临床实践或自我管理中易于评估的变量，开发了有和无BMD T评分的模型。该评估工具称为骨折指数，由一组七个变量组成，包括年龄，BMD T评分，50岁后骨折，50岁后产妇髋部骨折，体重小于或等于125磅（57公斤），吸烟状况和使用手臂从椅子上站起来。骨折指数被证明是预测髋部骨折，以及椎骨和非椎骨骨折。此外，使用EPIDOS骨折研究验证了该指数。骨折指数可用于老年绝经后妇女或其临床医生进行或不进行BMD测试，以评估髋关节和其他骨质疏松性骨折的5年风险，并有助于确定这些妇女是否需要进一步评估和治疗。
Due to the magnitude of the morbidity and mortality associated with untreated osteoporosis, it is essential that high-risk individuals be identified so that they can receive appropriate evaluation and treatment. The objective of this investigation was to develop a simple clinical assessment tool based on a small number of risk factors that could be used by women or their clinicians to assess their risk of fractures. Using data from the Study of Osteoporotic Fractures (SOF), a total of 7782 women age 65 years and older with bone mineral density (BMD) measurements and baseline risk factors were included in the analysis. A model with and without BMD T-scores was developed by identifying variables that could be easily assessed in either clinical practice or by self-administration. The assessment tool, called the FRACTURE Index, is comprised of a set of seven variables that include age, BMD T-score, fracture after age 50 years, maternal hip fracture after age 50, weight less than or equal to 125 pounds (57 kg), smoking status, and use of arms to stand up from a chair. The FRACTURE Index was shown to be predictive of hip fracture, as well as vertebral and nonvertebral fractures. In addition, this index was validated using the EPIDOS fracture study. The FRACTURE Index can be used either with or without BMD testing by older post-menopausal women or their clinicians to assess the 5-year risk of hip and other osteoporotic fractures, and could be useful in helping to determine the need for farther evaluation and treatment of these women.