Executive dysfunction and the course of geriatric depression
Executive dysfunction and the course of geriatric depression
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DOI：
10.1016/j.biopsych.2005.04.024
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发表时间：
2005-08-01
影响因子：
10.6
通讯作者：
Gunning-Dixon, F
中科院分区：
文献类型：
--
作者：
Alexopoulos, GS;Kiosses, DN;Gunning-Dixon, F
背景：执行功能障碍在老年抑郁症中很常见，并且在抑郁症状改善后仍然存在。本研究探讨了老年抑郁症患者的抑郁症状的过程中的关系，执行功能障碍：共112名非痴呆老年抑郁症患者参加了为期8周的西酞普兰试验，目标每日剂量为40毫克。执行功能进行了评估与痴呆评定量表的启动/持续分量表和Stroop色词测试。结果：异常启动/持续和异常Stroop色词评分均与老年抑郁症患者对西酞普兰的不良反应有关。特别是，起始/持续评分低于中位数（
Background: Executive dysfunction is common in geriatric depression and persists after improvement of depressive symptoms. This study examined the relationship of executive impairment to the course of depressive symptoms among elderly patients with major depression.Methods: A total of 112 nondemented elderly patients with major depression participated in an 8-week citalopram trial at a target daily dose of 40 mg. Executive functions were assessed with the initiation/perseveration subscale of the Dementia Rating Scale and the Stroop Color-word test. medical burden was rated with the Cumulative Illness Rating Scale.Results: Both abnormal initiation/perseveration and abnormal Stroop Color-Word scores were associated with an unfavorable response of geriatric depression to citalopram. In particular, initiation/perseveration scores below the median (