Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function
Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function
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DOI：
10.1016/j.placenta.2011.11.003
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发表时间：
2012-02-01
期刊：
影响因子：
3.8
通讯作者：
Tasken, K.
中科院分区：
文献类型：
--
作者：
Weedon-Fekjraer, M. S.;Tasken, K.
妊娠激素人绒毛膜促性腺激素（hCG）是维持早期妊娠所必需的，并参与调节孕酮的产生、蜕膜化和细胞滋养层分化。它结合并激活G蛋白偶联的促黄体激素/KG受体，激活cAMP/蛋白激酶A（PKA）途径，导致特异性细胞内靶蛋白磷酸化。cAMP信号传导的特异性通过产生由磷酸二酯酶控制的cAMP的局部池和通过在由A-激酶锚定蛋白组织的细胞内的超分子信号传导簇中PKA的离散空间和时间激活来确保。在这里，我们讨论PKA信号的时空调节响应hCG控制胎盘功能。(C)2012由IFPA和Elsevier Ltd.出版
The pregnancy hormone human chorionic gonadotropin (hCG) is essential to sustain early pregnancy and involved in regulation of progesterone production, decidualization, and cytotrophoblast differentiation. It binds to and activates the G-protein coupled luteinizing hormone/KG-receptor, activating the cAMP/protein kinase A (PKA) pathway which results in the phosphorylation of specific intracellular target proteins. Specificity in cAMP signaling is ensured by generation of localized pools of cAMP controlled by phosphodiesterases and by discrete spatial and temporal activation of PKA in supramolecular signaling clusters inside the cell organized by A-kinase-anchoring proteins. Here we discuss spatiotemporal regulation of PKA signaling in response to hCG controlling placental function. (C) 2012 Published by IFPA and Elsevier Ltd.