Mammalian Regeneration and Regenerative Medicine
Mammalian Regeneration and Regenerative Medicine
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DOI：
10.1002/bdrc.20137
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发表时间：
2008-12-01
影响因子：
2.1
通讯作者：
Han, Manjong
中科院分区：
文献类型：
--
作者：
Muneoka, Ken;Allan, Christopher H.;Han, Manjong
哺乳动物通常被认为再生能力较差，但有少数哺乳动物模型表现出强大的再生能力。人类和老鼠的指尖再生就是这样的系统之一。人类胎儿和小鼠指尖再生的体外研究显示出解剖学和分子方面的相似性，表明小鼠指尖是一种临床相关模型。与此同时，对小鼠指尖再生的遗传学研究已经确定了再生反应所需的信号通路，这些信号通路与已知对低等脊椎动物再生很重要的信号通路相似。此外，最近的研究表明，指尖再生涉及与两栖动物胚基相似的胚基的形成，从而在再生的临床应用和基础研究之间建立了概念桥梁。在这篇综述中，我们讨论了哺乳动物内源性再生系统的研究如何增强我们对再生机制的理解，并有助于阐明再生医学治疗策略的发展。出生缺陷研究（C 部分）84:265-280, 2008。(C) 2008 Wiley-Liss, Inc.
Mammals are generally considered to be poor regenerators, yet there are a handful of mammalian models that display a robust ability to regenerate. One such system is the regenerating tips of digits in both humans and mice. In vitro studies of regenerating fetal human and mouse digit tips display both anatomical and molecular similarities, indicating that the mouse digit is a clinically relevant model. At the same time, genetic studies on mouse digit tip regeneration have identified signaling pathways required for the regeneration response that parallel those known to be important for regeneration in lower vertebrates. In addition, recent studies establish that digit tip regeneration involves the formation of a blastema that shares similarities with the amphibian blastema, thus establishing a conceptual bridge between clinical application and basic research in regeneration. In this review we discuss how the study of endogenous regenerating mammalian systems is enhancing our understanding of regenerative mechanisms and helping to shed light on the development of therapeutic strategies in regenerative medicine. Birth Defects Research (Part C) 84:265-280, 2008. (C) 2008 Wiley-Liss, Inc.