Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome
Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome
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DOI：
10.1534/genetics.106.064980
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发表时间：
2007-08-01
期刊：
影响因子：
3.3
通讯作者：
Zou, Fei
中科院分区：
文献类型：
--
作者：
Huang, Hanwen;Eversley, Chevonne D.;Zou, Fei
贝叶斯方法已被开发用于遵循责任阈值模型的复杂二元性状的多个数量性状基因座(QTL)定位。与大多数一次只使用一个或几个标记的QTL作图方法不同，所提出的方法同时利用整个基因组的所有标记。通过模拟和实际数据分析，我们的贝叶斯方法的性能优于传统的单标记分析和区间作图，以确定与结直肠癌相关的候选基因。
A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.