The biochemistry and pharmacology of mesoamygdaloid dopamine neurons.
The biochemistry and pharmacology of mesoamygdaloid dopamine neurons.
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中杏仁核多巴胺神经元的生物化学和药理学。
DOI：
10.1111/j.1749-6632.1988.tb42105.x
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发表时间：
1988
影响因子：
5.2
通讯作者：
Mailman,RB
中科院分区：
文献类型：
--
作者：
Kilts,CD;Anderson,CM;Ely,TD;Mailman,RB
支配杏仁复合体组成核的DA神经元的种群在其推断的神经支配密度、脉冲活动的估计速率和对长期服用抗精神病药物的适应性反应方面有所不同。Mesoamygdaloid DA神经元有共同的张力抑制，神经末梢自身受体调节DA合成的情况下，与DA刺激的腺苷酸环化酶的nonassociation，和DA合成的调节受体介导的神经元反馈机制和终产物抑制。杏仁核复合体的输出似乎被组织成不同的功能，由组成核团来完成。目前的研究结果表明，DA传入在调制离散核的功能输出的不同作用。这一焦点影响的意义将是推测等待更完整的了解杏仁复合体中DA神经传递的生理学。支配离散杏仁核的DA神经元群体表现出不同于其他中脑DA系统的调节和信号转导和药理学机制的复合物。这些比较突出了这样一个事实，即延髓核和嗅结节不代表或反映边缘系统中的DA神经传递。对中脑边缘DA神经元的生理学、药理学和病理学的研究可以而且应该超越脑桥核和嗅结节，延伸到杏仁核和其他对边缘系统的组织至关重要的脑结构。我们认为，术语”中脑边缘”DA系统具有纯粹的解剖学内涵，更具体的术语（如，中央杏仁核）将更准确地表达该系统的功能组织。
Populations of DA neurons innervating the component nuclei of the amygdaloid complex differ in their inferred density of innervation, estimated rate of impulse activity, and adaptive response to the prolonged administration of antipsychotic drugs. Mesoamygdaloid DA neurons have in common the absence of tonically inhibitory, nerve terminal autoreceptors regulating DA synthesis, the nonassociation with a DA-stimulated adenylate cyclase, and the regulation of DA synthesis by receptor-mediated neuronal feedback mechanisms and end-product inhibition. The output of the amygdaloid complex appears to be organized into distinct functions subserved by component nuclei. The present findings suggest a differing role for DA afferents in modulating the functional output of discrete nuclei. The significance of this focal influence will be speculative pending a more complete understanding of the physiology of DA neurotransmission in the amygdaloid complex. Populations of DA neurons innervating discrete amygdaloid nuclei exhibit a composite of mechanisms of regulation and signal transduction and pharmacology that differ from that of other mesotelencephalic DA systems. These comparisons highlight the fact that the nucleus accumbens and olfactory tubercle do not represent or reflect DA neurotransmission in the limbic system. The study of the physiology, pharmacology, and pathology of mesolimbic DA neurons can and should extend beyond the nucleus accumbens and olfactory tubercle to the amygdala and other brain structures central to the organization of the limbic system. It is our opinion that the term" mesolimbic" DA system has purely anatomical connotations and that a more specific terminology (eg, meso-central amygdaloid nuclear) would express the functional organization of this system more accurately.