Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men
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DOI：
10.1136/hrt.2007.120774
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发表时间：
2008-04-01
期刊：
影响因子：
5.7
通讯作者：
Chaturvedi, N.
中科院分区：
文献类型：
--
作者：
Jafar, T. H.;Qadri, Z.;Chaturvedi, N.
印度-巴基斯坦人群是世界上冠状动脉疾病（CAD）风险最高的人群之一。对来自巴基斯坦卡拉奇12个随机选择的社区的3143名年龄≥ 40岁的成年人进行了一项基于人口的横断面调查。除吸烟外，女性比男性有更多的CAD风险因素（糖尿病、高血压、肥胖、血脂异常）。明确的CAD（病史和ECG上的Q波）在男性中的患病率高于女性（6.1% vs 4.0%; p = 0.009）。相比之下，女性中缺血性和主要ECG变化的发生率是男性的两倍（分别为29.4%和15.6%，21.0%和10.5%; p < 0.001）。代谢综合征对冠心病的所有指标都有很强的预测作用，但这并不能解释女性ECG异常的患病率高于男性。研究结果表明，巴基斯坦城市五分之一的中年人可能患有潜在的CAD。女性比男性面临更大的风险。
Indo-Pakistani populations have one of the highest risks of coronary artery disease (CAD) in the world. A population-based, cross-sectional survey was conducted on 3143 adults aged >= 40 years from 12 randomly selected communities in Karachi, Pakistan. Apart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men. Definite CAD (history and Q waves on ECG) was more prevalent in men than in women ( 6.1% vs 4.0%; p = 0.009). In contrast, ischaemic and major ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%, and 21.0% vs 10.5%; p < 0.001 for each, respectively). All measures of CAD were strongly predicted by the metabolic syndrome, but that failed to account for the greater prevalence of ECG abnormalities in women than in men. The findings indicate that one in five middle-aged adults in urban Pakistan may have underlying CAD. Women are at greater risk than men.