Transient improvement of left ventricular function after peripheral blood stem cell transplantation in a patient with myelodysplastic syndrome and dilated cardiomyopathy.
Transient improvement of left ventricular function after peripheral blood stem cell transplantation in a patient with myelodysplastic syndrome and dilated cardiomyopathy.
复制标题
骨髓增生异常综合征合并扩张型心肌病患者外周血干细胞移植后左心室功能的短暂改善。
DOI：
10.1253/circj.68.958
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Y. Maruyama
中科院分区：
文献类型：
--
作者：
K. Ogawa;H. Yaoita;M. Okamoto;K. Ikeda;T. Shichishima;H. Ohto;K. Maehara;Y. Maruyama
一位患有骨髓增生异常综合征（MDS）和扩张型心肌病（DCM）的患者在外周血干细胞移植（PBSCT）后心功能得到短暂改善。当他入院接受PBSCT时，胸部X线检查显示心脏肥大，Tc-99 m定量门控单光子发射计算机断层扫描（QGS）显示左心室（LV）容积增加和LV射血分数（LVEF）降低。冠状动脉造影显示没有冠状动脉疾病的证据。左心室造影显示与QGS相似的结果，心肌活检的结果与DCM一致。在他的兄弟作为供体的allo-PBSCT成功后三个月，QGS图像上的心脏肥大已减弱，LV体积减小，LVEF增加。然而，10个月后，他的心脏功能恶化。心功能的变化与血液学变化（如血红蛋白水平）无关。
A patient who had myelodysplastic syndrome (MDS) and dilated cardiomyopathy (DCM) had a transient improvement of cardiac function after peripheral blood stem cell transplantation (PBSCT). When he was admitted to hospital for PBSCT, a chest X ray showed cardiomegaly, and Tc-99m quantitative gated single photon emission computed tomography (QGS) showed increases in left ventricular (LV) volumes and a decrease in LV ejection fraction (LVEF). A coronary angiogram showed no evidence of coronary artery disease. Left ventriculography showed similar findings as QGS, and the findings from a myocardial biopsy were compatible with DCM. Three months after a successful allo-PBSCT with his brother as the donor, the cardiomegaly had been attenuated, the LV volumes decreased and LVEF increased on the QGS images. However, 10 months later, his cardiac function had deteriorated. The changes in cardiac function did not correlate with the hematological changes, such as the hemoglobin level.