Regulation of Stem Cells by Cullin-RING Ligase
Regulation of Stem Cells by Cullin-RING Ligase
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DOI：
10.1007/978-981-15-1025-0_6
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Zhang, Lingqiang
中科院分区：
文献类型：
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作者：
Fu, Lin;Cui, Chun-Ping;Zhang, Lingqiang
干细胞可以保持静止，自我更新，并分化成许多类型的细胞，甚至是癌症干细胞。这些复杂过程的协调维持有机体的稳态。泛素化是一个重要的翻译后修饰过程，调节蛋白质的稳定性和活性。干细胞相关蛋白的泛素化水平与干细胞特性密切相关。Cullin-RING连接酶（CRL）是E3泛素连接酶中最大的家族，约占蛋白酶体降解蛋白的20%。在这篇综述中，我们讨论了CRLs在干细胞稳态，自我更新和分化中的作用，并阐述了其泛素化底物。此外，我们还讨论了CRL对癌症干细胞形成的影响，这可能为癌症提供有希望的治疗策略。
Stem cells can remain quiescent, self-renewal, and differentiate into many types of cells and even cancer stem cells. The coordination of these complex processes maintains the homeostasis of the organism. Ubiquitination is an important posttranslational modification process that regulates protein stability and activity. The ubiquitination levels of stem cell-associated proteins are closely related with stem cell characteristics. Cullin-RING Ligases (CRLs) are the largest family of E3 ubiquitin ligases, accounting for approximately 20% of proteins degraded by proteasome. In this review, we discuss the role of CRLs in stem cell homeostasis, self-renewal, and differentiation and expound their ubiquitination substrates. In addition, we also discuss the effect of CRLs on the formation of cancer stem cells that may provide promising therapy strategies for cancer.