Enhanced covariance spectroscopy from minimal datasets
Enhanced covariance spectroscopy from minimal datasets
复制标题
DOI：
10.1021/ja065522e
复制
发表时间：
2006-12-13
影响因子：
15
通讯作者：
Brueschweiler, Rafael
中科院分区：
文献类型：
--
作者：
Chen, Yanbin;Zhang, Fengli;Brueschweiler, Rafael
描述了一种新的方法，用于确定可靠的高分辨率homeNMR协方差谱从最小的数据集。它使用沿着间接维度的稀疏采样方案以及对有限采样效应的全面分析，以消除虚假相关性。该方案，这是证明TOCSY和COSY，提供了一个显着的速度比目前的方法，使其适合高通量筛选应用。
A novel approach is described for the determination of reliable high-resolution homonuclear NMR covariance spectra from minimal datasets. It uses a sparse sampling scheme along the indirect dimension together with a comprehensive analysis of finite sampling effects that eliminates spurious correlations. The scheme, which is demonstrated for TOCSY and COSY, offers a substantial speed up over current methods, rendering it suitable for high-throughput screening applications.