Clinical features of ceroid lipofuscinosis in border collie dogs.
Clinical features of ceroid lipofuscinosis in border collie dogs.
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边境牧羊犬蜡样脂褐质沉着症的临床特征。
DOI：
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发表时间：
1991
影响因子：
1.1
通讯作者：
R. Mitten
中科院分区：
文献类型：
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作者：
V. Studdert;R. Mitten
通过17只相关边境牧羊犬的组织病理学和组织化学检查，以及6只产仔犬的临床症状，诊断出Ceroid脂褐质病。行为改变，首先是多动和后来的攻击性，开始于16至23个月（平均19.5个月）。运动异常和失明的平均年龄分别为20.8个月和21.2个月。所有犬在出现临床症状1 ~ 6个月后被安乐死，平均年龄23.1个月。系谱数据支持常染色体隐性遗传模式。
Ceroid lipofuscinosis was diagnosed by histopathological and histochemical findings in 17 related border collie dogs and by clinical signs in 6 of their litter mates. Behavioural changes, first hyperactivity and later aggression, commenced at 16 to 23 (mean 19.5) months of age. Motor abnormalities and blindness were observed at the mean ages of 20.8 and 21.2 months, respectively. All dogs were euthanased 1 to 6 months after the onset of clinical signs, mean age 23.1 months. Pedigree data supported an autosomal recessive mode of inheritance.
DOI：
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发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Palmer,DN;Husbands,DR;Winter,PJ;Blunt,JW;Jolly,RD
通讯作者：
Jolly,RD