Optimal cut-off score of the Edinburgh Postnatal Depression Scale for major depressive episode during pregnancy in Japan
Optimal cut-off score of the Edinburgh Postnatal Depression Scale for major depressive episode during pregnancy in Japan
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DOI：
10.1111/pcn.12562
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发表时间：
2017-12-01
影响因子：
11.9
通讯作者：
Sano, Yo
中科院分区：
文献类型：
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作者：
Usuda, Kentaro;Nishi, Daisuke;Sano, Yo
目的：怀孕期间的抑郁症会对母亲和孩子产生不利影响。由于产前抑郁症是产后抑郁症的预测因素，早期发现可能会预防产后抑郁症。爱丁堡产后抑郁量表（EPDS）在围产期经常使用，但怀孕期间的截止分数尚未在日本人群中得到验证。我们的目的是明确日本妊娠中期的最佳 EPDS 截止分数。方法：我们招募了 20 岁或以上、孕 12-24 周的孕妇，并邀请 EPDS 得分 >= 9 的孕妇参与本研究。在进行 EPDS 的同时，还进行了日语版的小型国际神经精神病学访谈，以确定重度抑郁发作的诊断。然后，我们计算了 EPDS 的受试者操作曲线、敏感性和特异性以及阳性和阴性预测值。结果：除一名参与者（妊娠 12 周）外，所有 210 名参与者均处于妊娠中期。二十名参与者被诊断患有重度抑郁症。截止分数设置为 13 分，曲线下面积为 0.956；敏感性和特异性分别为 90.0% 和 92.1% [首次在线发布后于 2017 年 11 月 10 日添加更正：特异性百分比已从 79.0% 更正为 92.1%。]；阳性和阴性预测值分别为 54.5% 和 98.9%。 结论：据我们所知，这是日本第一项明确妊娠中期最佳 EPDS 截止分数的研究。这一发现将有助于日本适当筛查产前抑郁症。
Aim: Depression during pregnancy adversely affects both mother and child. As antenatal depression is a predictor of postnatal depression, early detection might prevent postnatal depression. The Edinburgh Postnatal Depression Scale (EPDS) is frequently used during the perinatal period, but the cut-off score during pregnancy has not been verified for the Japanese population. We aimed to clarify the optimal EPDS cut-off score in mid-pregnancy in Japan.Methods: We recruited pregnant women aged 20 years or older at 12-24 gestational weeks and those who scored >= 9 on the EPDS were invited to participate in this study. In parallel with the EPDS, the Japanese version of the Mini-International Neuropsychiatric Interview was administered to determine diagnosis of major depressive episode. We then calculated the receiver-operator curve, sensitivity and specificity, and positive and negative predictive values for the EPDS.Results: All 210 participants were in the second trimester except for one (12 gestational weeks). Twenty participants were diagnosed with major depressive episode. With a cut-off score set at 13 points, the area under the curve was 0.956; sensitivity and specificity were 90.0% and 92.1% [Correction added on 10 November 2017, after first online publication: The percentage for specificity has been corrected from 79.0% to 92.1%.], respectively; and positive and negative predictive values were 54.5% and 98.9%, respectively.Conclusion: To our knowledge, this is the first study to clarify the optimal EPDS cut-off score in the second trimester for Japan. This finding will be helpful for appropriate screening for antenatal depression in Japan.