Effect of a 7.2% hypertonic saline solution infusion on arterial blood pressure, serum sodium concentration and osmotic pressure in normovolemic heifers
Effect of a 7.2% hypertonic saline solution infusion on arterial blood pressure, serum sodium concentration and osmotic pressure in normovolemic heifers
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DOI：
10.1292/jvms.60.799
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发表时间：
1998-07-01
影响因子：
1.2
通讯作者：
Iwabuchi, S
中科院分区：
文献类型：
--
作者：
Suzuki, K;Ajito, T;Iwabuchi, S
小体积（5 ml/kg）或大体积静脉（iv）输注的影响（15 ml/kg）高渗盐溶液（HSS; 7.2%，2，400 mOsmol/kg.H2O）和静脉输注5 ml/kg等渗盐水溶液在清醒的小母牛中研究了（ISS; 300 mOsmol/kg.H2O）对血浆容量、动脉血压、血清钠浓度和渗透压的影响。开始补液后，监测9头小母牛（3头小母牛/组）120 min。5 ml/kg HSS和15 ml/kg HSS的相对血浆容量（rPV）逐渐增加，t=5 min时分别为137.7 +/- 2.4%，t=15 min时分别为145.2 +/-5.4%。5 ml/kg HSS组的扩张血浆容量在120分钟前保持在高达10%的高水平，但15 ml/kg HSS组则不然。5 ml/kg HSS静脉输注可诱导大鼠出现一过性高渗血症，（305.3 +/- 4.0 mOsmol/kg.H2O）和钠水平（155.7 +/- 3.5 mM/l）。然而，15 ml/kg HSS输注诱导恒定高渗透压水平（321.7-336.7 mOsmol/kg.H2O）和高钠血症（162.8-170.0 mM/l）。在ISS和5 ml/kg HSS组中，未观察到PaO 2变化。与t=0 min值相比，15 ml/kg HSS输注在t=30 min时诱导氧分压显著降低。基于这些发现，可以快速安全地向牛输注小体积（5 ml/kg）HSS，以扩大血浆容量，而不会诱导高钠血症。因此，建议在牛的初始田间复苏中输注5 ml/kg HSS。
The effects of an intravenous (iv) infusion of a small volume (5 ml/kg) or large volume (15 ml/kg) of hypertonic saline solution (HSS; 7.2%, 2,400 mOsmol/kg.H2O) and those of an iv infusion of 5 ml/kg isotonic saline solution (ISS; 300 mOsmol/kg.H2O) on plasma volume, arterial blood pressure, serum sodium concentrations and osmotic pressure were investigated in conscious heifers. Nine heifers (3 heifers/group) were monitored for 120 min after the initiation of fluid replacement. The relative plasma volume (rPV) in the 5 ml/kg HSS and 15 ml/kg HSS progressively increased to 137.7 +/- 2.4% at t=5 min and 145.2 +/-:5.4% at t=15 min, respectively. The expanding plasma volume in the 5 ml/kg HSS group remained at an up to 10% higher level until 120 min, but not in the 15 ml/kg HSS group. The 5 ml/kg, HSS infusion induced transit high-osmotic (305.3 +/- 4.0 mOsmol/kg.H2O) and sodium levels (155.7 +/- 3.5 mM/l) at t=5 min. However, the 15 ml/kg HSS infusion induced constant high-osmotic level (321.7-336.7 mOsmol/kg.H2O) and hypernatremia (162.8-170.0 mM/l) from t-10 min to the rest of the experiment period. In the ISS and 5 ml/kg HSS groups, no changes in PaO2, were observed. The 15 ml/kg HSS infusion induced a significant decrease in the partial pressure of oxygen at the t=30 min compared io the t=0 min values. On the basis of these findings, a small volume (5 ml/kg) HSS infusion can be rapidly and safely administered to cattle for expanding the plasma volume without inducing hypernatremia. A 5 ml/kg HSS infusion is thus recommended for the initial field resuscitation of cattle.