The first report of CCR5 delta 32 mutant in Thai injecting drug users.
The first report of CCR5 delta 32 mutant in Thai injecting drug users.
复制标题
泰国注射吸毒者中首次报告 CCR5 delta 32 突变体。
DOI：
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发表时间：
2000
影响因子：
5
通讯作者：
T. Phutiprawan
中科院分区：
文献类型：
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作者：
N. Ruchusatsawat;S. Vongsheree;H. Thaisri;T. Phutiprawan
CCR5是一种趋化因子受体，是嗜巨噬细胞HIV-1的主要辅助受体，是病毒传播中最重要的变异。已经证明，CCR5基因32 bp缺失的纯合基因型（delta32CCR5）显示出对HIV-1感染的高度抗性。为了证明delta32CCR5在泰国本地人中确实存在，我们用PCR和DNA测序方法测定了860名泰国注射吸毒者（IDUs）的CCR5基因型和等位基因频率。其中6例（0.7%）为CCR5/delta32CCR5杂合子，未发现纯合子。总delta32CCR5等位基因频率为0.0035，HIV-1血清阴性（n = 490）和血清阳性（n = 370） idu分别为0.0051和0.0004，差异无统计学意义（p = 0.3776）。在这里，我们报告delta32CCR5确实存在于泰国idu中，就像它存在于其他人类种族中一样。如此低的等位基因频率可能表明这种突变在泰国注射吸毒者的HIV-1传播中没有重要作用。
CCR5, a chemokine receptor, is the principal coreceptor for macrophage-tropic HIV-1 which is the most important variant for viral transmission. It has been demonstrated that a homozygous genotype of a 32-bp deletion in CCR5 gene (delta32CCR5) shows a high degree of resistance to HIV-1 infection. To demonstrate that delta32CCR5 does exist in Thai natives, the CCR5 genotypes and allelic frequencies in 860 Thai injecting drug users (IDUs) were determined by PCR and DNA sequencing. Of these, six (0.7%) were CCR5/delta32CCR5 heterozygotes and no homozygote was found. The overall delta32CCR5 allelic frequency was 0.0035 and in HIV-1 seronegative (n = 490) and seropositive (n = 370) IDUs were 0.0051 and 0.0004, respectively, which were not significantly different (p = 0.3776). Here we report that the delta32CCR5 does exist in Thai IDUs as it is present in other human races. Such low allelic frequency may indicate that this mutation does not attribute a significant role in HIV-1 transmission in Thai IDUs.
影响因子：
64.8
作者：
Samson, M;Libert, F;Parmentier, M
通讯作者：
Parmentier, M
抵抗艾滋病毒感染和艾滋病进展
DOI：
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发表时间：
2012
期刊：
影响因子：
--
作者：
Miyazawa;M
通讯作者：
M