Chemotherapy of rare skin adnexal tumors: a review of literature.
Chemotherapy of rare skin adnexal tumors: a review of literature.
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发表时间：
2014-10
影响因子：
2
通讯作者：
F. de Iuliis;L. Amoroso;L. Taglieri;S. Vendittozzi;L. Blasi;G. Salerno;R. Lanza;S. Scarpa
中科院分区：
文献类型：
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作者：
F. de Iuliis;L. Amoroso;L. Taglieri;S. Vendittozzi;L. Blasi;G. Salerno;R. Lanza;S. Scarpa
恶性皮肤附属器肿瘤是一种罕见的肿瘤，它起源于皮肤的附属器上皮结构：毛囊，或皮脂腺，顶浆腺或外分泌腺。其中，小汗腺汗孔癌是最常见的，与其他更常见形式的非黑色素瘤皮肤癌相比具有侵袭性行为。只有少数报道描述了转移性附件肿瘤的治疗，并且对于更好的化疗策略没有达成共识。由于病例较少且缺乏随机临床试验，因此收集这些肿瘤的临床经验非常重要。这些腺癌大多数是非常积极的，也是化疗耐药，只有靶向治疗可能对患者生存的影响。因此，有必要对这些疾病的生物学进行进一步研究。本文旨在探讨皮肤附件恶性肿瘤的治疗方法，并提出一些基于靶向治疗的治疗方案。
Malignant skin adnexal tumors are rare neoplasms which are derived from adnexal epithelial structures of the skin: hair follicle, or sebaceous, apocrine or eccrine glands. Among them, eccrine porocarcinoma is the most frequent, with an aggressive behavior compared to other more common forms of non-melanoma skin cancer. Only few reports describe the treatment of metastatic adnexal tumors, and there is no consensus about the better strategy of chemotherapy. Given the few cases and the absence of randomized clinical trials, it is important to collect clinical experiences on these tumors. Most of these adenocarcinomas are very aggressive and also chemoresistant, and only a targeted-therapy could have an impact on patient survival. Therefore, further studies on the biology of these diseases are necessary. The purpose of the present review is to discuss the treatment of malignant neoplasms of cutaneous adnexae and to suggest some future therapeutic options based on targeted-therapy.