Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.
Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.
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DOI：
10.1038/srep31268
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发表时间：
2016-08-08
影响因子：
4.6
通讯作者：
Moriyama T
中科院分区：
文献类型：
--
作者：
Kugo H;Zaima N;Tanaka H;Mouri Y;Yanagimoto K;Hayamizu K;Hashimoto K;Sasaki T;Sano M;Yata T;Urano T;Setou M;Unno N;Moriyama T
腹主动脉瘤（AAA）是一种涉及腹主动脉逐渐扩张的血管疾病。据报道，AAA 的发生与血管壁炎症有关；然而，AAA破裂的机制尚不完全清楚。在这项研究中，我们使用低灌注诱导的动物模型研究了 AAA 破裂的机制。我们发现，给予三油酸甘油酯会增加动物模型中的 AAA 破裂率，并且与未破裂的血管壁相比，破裂的血管壁中的脂肪细胞数量有所增加。在破裂组中，脂肪细胞周围区域的巨噬细胞浸润以及基质金属蛋白酶2和9的蛋白水平增加，而与没有脂肪细胞的区域相比，有脂肪细胞区域的胶原蛋白阳性区域减少。与三油酸甘油酯给药组相比，服用鱼油可抑制脂肪细胞肥大，减少脂肪细胞的数量和大小，并使 AAA 破裂的风险率降低 0.23。在人类 AAA 样本中，外膜中甘油三酯的含量与 AAA 的直径相关。这些结果表明AAA破裂与血管壁脂肪细胞的异常出现有关。
Abdominal aortic aneurysm (AAA) is a vascular disease involving the gradual dilation of the abdominal aorta. It has been reported that development of AAA is associated with inflammation of the vascular wall; however, the mechanism of AAA rupture is not fully understood. In this study, we investigated the mechanism underlying AAA rupture using a hypoperfusion-induced animal model. We found that the administration of triolein increased the AAA rupture rate in the animal model and that the number of adipocytes was increased in ruptured vascular walls compared to non-ruptured walls. In the ruptured group, macrophage infiltration and the protein levels of matrix metalloproteinases 2 and 9 were increased in the areas around adipocytes, while collagen-positive areas were decreased in the areas with adipocytes compared to those without adipocytes. The administration of fish oil, which suppresses adipocyte hypertrophy, decreased the number and size of adipocytes, as well as decreased the risk of AAA rupture ratio by 0.23 compared to the triolein administered group. In human AAA samples, the amount of triglyceride in the adventitia was correlated with the diameter of the AAA. These results suggest that AAA rupture is related to the abnormal appearance of adipocytes in the vascular wall.