Psychopathy's influence on the coupling between hypothalamic-pituitary-adrenal and -gonadal axes among incarcerated adolescents.
Psychopathy's influence on the coupling between hypothalamic-pituitary-adrenal and -gonadal axes among incarcerated adolescents.
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DOI：
10.1002/dev.21111
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发表时间：
2014-04
影响因子：
2.2
通讯作者：
Shirtcliff EA
中科院分区：
文献类型：
--
作者：
Johnson MM;Dismukes AR;Vitacco MJ;Breiman C;Fleury D;Shirtcliff EA
行为障碍（CD）是一种异质性诊断，导致研究人员开始研究这种疾病的神经生物学机制。目前被考虑纳入DSM-V的CD的一个描述符是冷酷无情（CU）特质。CU特征被认为有神经内分泌基础，但很少有人知道下丘脑-垂体-肾上腺（HPA）和性腺（HPG）激素在精神病特征的背景下。目前的研究旨在确定HPA和HPG激素之间的日常耦合模式，以澄清与精神病/CU特征相关的不同神经生物学基础。招募了50名符合CD标准的被监禁青少年男性，并在两天内提供了10份唾液样本。参与者在第三天完成了精神病检查表青年版（PCL：YV）和冷酷无情感特质清单（ICU）。昼夜皮质醇，睾酮和脱氢表雄酮功能通过分层线性建模。从管理的措施，精神病分量表被用来作为这些激素之间的日常耦合模式的预测。结果表明，这三种激素是紧密耦合的。此外，更高的PCL-YV人际关系得分与所有三种激素之间的更大耦合相关，而更高的ICU冷酷得分与睾酮与皮质醇和DHEA的更大解偶联相关。目前的研究是新颖的，其重点是测试耦合的HPA和HPG激素之间的监禁青少年男性。结果表明，情感和人际精神病特质的特点是独特的HPA和HPG耦合。
Conduct disorder (CD) is a heterogeneous diagnosis, leading researchers to initiate research into the neurobiological mechanisms underlying this disorder. One specifier of CD currently considered for inclusion in the DSM-V is callous-unemotional (CU) traits. CU traits are thought to have neuroendocrine underpinnings, yet little is known about Hypothalamic-Pituitary-Adrenal (HPA) and –Gonadal (HPG) hormones in the context of psychopathic traits. The current study sought to identify daily coupling patterns between HPA and HPG hormones in order to clarify distinct neurobiological underpinning associated with psychopathic/CU traits. Fifty incarcerated adolescent males who met criteria for CD were recruited and provided 10 saliva samples across two days. Participants completed the Psychopathy Checklist Youth Version (PCL:YV) and Inventory of Callous Unemotional Traits (ICU) on a third day. Diurnal cortisol, testosterone, and DHEA functioning was modeled via hierarchical linear modeling. Psychopathy subscales from the measures administered were used as predictors of daily coupling patterns between these hormones. Results indicated that all three hormones were tightly coupled. Further, higher PCL-YV interpersonal scores related to greater coupling between all three hormones, whereas higher ICU callousness scores related to greater uncoupling of testosterone with cortisol and DHEA. The current study is novel in its emphasis on testing the coupling of HPA and HPG hormones among incarcerated adolescent males. Results suggest that affective and interpersonal psychopathic traits are marked by unique HPA- and HPG- coupling.