Design strategies of biodegradable scaffolds for tissue regeneration.
Design strategies of biodegradable scaffolds for tissue regeneration.
复制标题
DOI：
10.4137/becb.s10961
复制
发表时间：
2014
影响因子：
2.8
通讯作者：
Zakhem E
中科院分区：
文献类型：
--
作者：
Bitar KN;Zakhem E
有许多可用的可生物降解材料可以用作再生医学的支架。目前，人们非常重视脚手架的设计阶段。材料可以设计成具有不同的特性，以便与特定的应用相匹配。改性支架增强了其生物活性，提高了再生能力。以后可以使用几种组织工程工具对支架的修饰进行表征。除了材料之外，细胞来源也是再生过程中的重要组成部分。经修饰的材料必须能够支持不同类型细胞的生存和生长。细胞和改良的生物材料共同促进了工程组织的重塑，从而影响了它的性能。本文综述了近年来支架材料的设计进展，包括物理修饰和化学修饰。这篇综述的最后部分还讨论了涉及细胞生存能力的设计过程。
There are numerous available biodegradable materials that can be used as scaffolds in regenerative medicine. Currently, there is a huge emphasis on the designing phase of the scaffolds. Materials can be designed to have different properties in order to match the specific application. Modifying scaffolds enhances their bioactivity and improves the regeneration capacity. Modifications of the scaffolds can be later characterized using several tissue engineering tools. In addition to the material, cell source is an important component of the regeneration process. Modified materials must be able to support survival and growth of different cell types. Together, cells and modified biomaterials contribute to the remodeling of the engineered tissue, which affects its performance. This review focuses on the recent advancements in the designs of the scaffolds including the physical and chemical modifications. The last part of this review also discusses designing processes that involve viability of cells.