Glutamate-like immunoreactivity in the leech central nervous system.
Glutamate-like immunoreactivity in the leech central nervous system.
复制标题
水蛭中枢神经系统中的谷氨酸样免疫反应性。
DOI：
10.1007/bf00316073
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Cohen,AH
中科院分区：
文献类型：
--
作者：
Brodfuehrer,PD;Cohen,AH
用谷氨酸单克隆抗体测定了水蛭中枢神经系统（CNS）谷氨酸样免疫反应神经元的分布。谷氨酸样免疫反应神经元（GINs）被发现定位于水蛭中枢神经系统的前部：在第一节神经节和食管下神经节。正好有五对GIN与谷氨酸抗体反应。两对内侧GIN位于食管下神经节中，与第一节神经节中的两对内侧GIN具有一些共同的形态学特征。另外一对外侧GIN也位于节段神经节1。一对谷氨酸样免疫反应神经元，这是潜在的同源物的外侧对GIN节1，偶尔观察到更多的后节神经节沿着与一组选择性的神经元过程。因此，水蛭中枢神经系统中只有一小部分局部神经元似乎使用谷氨酸作为其神经递质。
Using a monoclonal antibody for glutamate the distribution was determined of glutamate-like immunoreactive neurons in the leech central nervous system (CNS). Glutamate-like immunoreactive neurons (GINs) were found to be localized to the anterior portion of the leech CNS: in the first segmental ganglion and in the subesophageal ganglion. Exactly five pairs of GINs consistently reacted with the glutamate antibody. Two medial pairs of GINs were located in the subesophageal ganglion and shared several morphological characteristics with two medial pairs of GINs in the first segmental ganglion. An additional lateral pair of GINs was also located in segmental ganglion 1. A pair of glutamate-like immunoreactive neurons, which are potential homologs of the lateral pair of GINs in segmental ganglion 1, were occasionally observed in more posterior segmental ganglia along with a selective group of neuronal processes. Thus only a small, localized population of neurons in the leech CNS appears to use glutamate as their neurotransmitter.