SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes.
SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes.
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DOI：
10.1002/jcsm.12048
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Morley JE
中科院分区：
文献类型：
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作者：
Malmstrom TK;Miller DK;Simonsick EM;Ferrucci L;Morley JE
一个简短，廉价的筛选测试肌肉减少症将有助于临床医生和他们的病人。为了筛查肌肉减少症患者，我们根据肌肉减少症的主要特征或后果开发了一个简单的五项问卷（SARC-F）。我们调查了SARC‐F在非裔美国人健康（AAH）研究、巴尔的摩老龄化纵向研究（BLSA）和国家健康与营养调查（NHANES）中的效用。使用Cronbach's alpha确定SARC‐F的内部一致性可靠性。我们使用主成分分析和标准效度评估SARC-F因子效度，通过检查其与基于考试的肌肉减少症指标的相关性。使用死亡率和健康结局SARC‐F评分高（≥4）与低（<4）的患者之间的横截面和纵向差异来检查结构效度。SARC‐F表现出良好的内部一致性可靠性和析因、标准和结构效度。SARC-F评分≥ 4的AAH参与者的日常生活工具活动（IADL）缺陷较多，椅子站立时间较慢，握力较低，短期身体表现电池评分较低，最近住院的可能性较高，步态速度<0.8 m/s。AAH中SARC‐F评分≥ 4分也与6年IADL缺陷、椅子站立时间较慢、短期体能组合评分较低、步态速度<0. 8 m/s、近期住院和死亡率相关。在横断面比较中，BLSA队列中SARC‐F评分≥ 4与IADL缺陷较多和握力（双手）较低相关，与IADL缺陷、握力（双手）较低和随访时死亡率相关。在横断面分析中，SARC‐F评分≥ 4的NHANES参与者的20英尺步行时间较慢，膝关节伸肌力量峰值较低，最近住院的可能性更大。SARC‐F被证明在AAH、BLSA和NHANES中具有内部一致性和有效性，可用于检测存在肌肉减少症不良结局风险的人员。
A brief, inexpensive screening test for sarcopenia would be helpful for clinicians and their patients. To screen for persons with sarcopenia, we developed a simple five‐item questionnaire (SARC‐F) based on cardinal features or consequences of sarcopenia. We investigated the utility of SARC‐F in the African American Health (AAH) study, Baltimore Longitudinal Study of Aging (BLSA), and National Health and Nutrition Examination Survey (NHANES). Internal consistency reliability for SARC‐F was determined using Cronbach's alpha. We evaluated SARC‐F factorial validity using principal components analysis and criterion validity by examining its association with exam‐based indicators of sarcopenia. Construct validity was examined using cross‐sectional and longitudinal differences among those with high (≥4) vs. low (<4) SARC‐F scores for mortality and health outcomes. SARC‐F exhibited good internal consistency reliability and factorial, criterion, and construct validity. AAH participants with SARC‐F scores ≥ 4 had more Instrumental Activity of Daily Living (IADL) deficits, slower chair stand times, lower grip strength, lower short physical performance battery scores, and a higher likelihood of recent hospitalization and of having a gait speed of <0.8 m/s. SARC‐F scores ≥ 4 in AAH also were associated with 6 year IADL deficits, slower chair stand times, lower short physical performance battery scores, having a gait speed of <0.8 m/s, being hospitalized recently, and mortality. SARC‐F scores ≥ 4 in the BLSA cohort were associated with having more IADL deficits and lower grip strength (both hands) in cross‐sectional comparisons and with IADL deficits, lower grip strength (both hands), and mortality at follow‐up. NHANES participants with SARC‐F scores ≥ 4 had slower 20 ft walk times, had lower peak force knee extensor strength, and were more likely to have been hospitalized recently in cross‐sectional analyses. The SARC‐F proved internally consistent and valid for detecting persons at risk for adverse outcomes from sarcopenia in AAH, BLSA, and NHANES.