Thiol Compounds. V. Absolute Configuration and Crystal Structure of (4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic Acid
Thiol Compounds. V. Absolute Configuration and Crystal Structure of (4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic Acid
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硫醇化合物。
DOI：
10.1248/cpb.30.484
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
N. Yasuoka
中科院分区：
文献类型：
--
作者：
M. Oya;E. Kato;J. Iwao;N. Yasuoka
The absolute configuration of (4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid (11a), SA 446, which has a potent inhibitory activity against angiotensin I-converting enzyme (ACE), was determined to be (2R, 4R) by nuclear magnetic resonance (NMR) spectroscopy, specific rotation measurement and X-ray crystallography. The structure-activity relationships of the (2R, 4R)-and (2S, 4R)-isomers are discussed, and stereoselective acylation of (4R)-2-aryl-4-thiazolidinecarboxylic acids (1-3) is also described.
