Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer
Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer
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DOI：
10.1016/j.jtcvs.2004.11.021
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发表时间：
2005-07-01
影响因子：
6
通讯作者：
Nishiwaki, Y
中科院分区：
文献类型：
--
作者：
Shimizu, K;Yoshida, J;Nishiwaki, Y
目的：尽管非小细胞肺癌的脏层胸膜侵犯被认为是一个预后不良的因素，但缺乏进一步的信息，特别是与其他临床病理预后因素的关系。我们评估了内脏胸膜浸润和其他临床病理特征之间的关系，并评估其作为预后因素的意义。方法：我们回顾了1074例手术切除的T1/2非小细胞肺癌的临床病理特征和预后。根据内脏胸膜侵犯情况将患者分为2组（内脏胸膜侵犯组和非内脏胸膜侵犯组）。比较两组患者的年龄、性别、组织学、肿瘤大小、肿瘤分化程度、淋巴结转移、淋巴管浸润、血管浸润、瘢痕分级、核密度、有丝分裂指数、血清癌胚抗原水平和生存率。结果：在288例（26.8%）切除的标本中发现内脏胸膜侵犯。非内脏胸膜侵犯组5年生存率为76.0%，10年生存率为53.2%，内脏胸膜侵犯组5年生存率为49.8%，10年生存率为37.0%。组间差异有高度显著性（P
Objective: Although visceral pleural invasion by non-small cell lung cancer is considered a poor-prognostic factor, further information is lacking, especially in relation to other clinicopathologic prognostic factors. We assessed the relationship between visceral pleural invasion and other clinicopathologic characteristics and evaluated its significance as a prognostic factor.Methods: We reviewed 1074 patients with surgically resected T1/2 non-small cell lung cancer for their clinicopathologic characteristics and prognoses. The patients were divided into 2 groups according to visceral pleural invasion status (visceral pleural invasion group and non-visceral pleural invasion group). Both groups were compared with regard to age, sex, histology, tumor size, tumor differentiation, lymph node involvement, lymphatic invasion, vascular invasion, scar grade, nuclear atypia, mitotic index, serum carcinoembryonic antigen level, and survival. Univariate and multivariate analyses were conducted.Results: Visceral pleural invasion was identified in 288 (26.8%) of the resected specimens. Survival was 76.0% at 5 years and 53.2% at 10 years in the non-visceral pleural invasion group and was 49.8% at 5 years and 37.0% at 10 years in the visceral pleural invasion group. The difference between groups was highly significant (P