A Dual-Catalysis/Anion-Binding Approach to the Kinetic Resolution of Allylic Amines
A Dual-Catalysis/Anion-Binding Approach to the Kinetic Resolution of Allylic Amines
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DOI：
10.1021/ol200712b
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发表时间：
2011-05-06
期刊：
影响因子：
5.2
通讯作者：
Seidel, Daniel
中科院分区：
文献类型：
--
作者：
Klauber, Eric G.;Mittal, Nisha;Seidel, Daniel
双催化方法使烯丙胺的小分子催化动力学分解成为可能。采用2mol %的4-吡咯烷酮吡啶（PPY）和一种现成的手性氢键助催化剂，实现了烯丙胺的第一次非酶动力学分解，分解系数高达20倍。
A dual-catalysis approach enables the small-molecule catalyzed kinetic resolution of allylic amines by acylation. By employing 2 mol % of each 4-(pyrrolidin D)pyridine (PPY) and a readily available chiral hydrogen-bonding cocatalyst, the first nonenzymatic kinetic resolution of allylic amines was accomplished with s factors of up to 20.