Development of a four-dimensional image-guided radiotherapy system with a gimbaled X-ray head
Development of a four-dimensional image-guided radiotherapy system with a gimbaled X-ray head
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DOI：
10.1016/j.ijrobp.2006.04.044
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发表时间：
2006-09-01
影响因子：
7
通讯作者：
Hiraoka, Masahiro
中科院分区：
文献类型：
--
作者：
Kamino, Yuichiro;Takayama, Kenji;Hiraoka, Masahiro
目的：开发和评估一种新型四维图像引导放射治疗系统，该系统能够实现精确设置、实时肿瘤跟踪和追踪照射。方法和材料：该系统具有创新的万向架X射线头，可以实现小角度（+/- 2.4度）旋转（平移和倾斜）沿着两个正交万向架。该设计通过主动补偿机械变形和快速追踪目标来提供等中心处的精确射束定位。X射线头由超轻C波段直线加速器和多叶准直器组成。万向X射线头安装在刚性O形环结构上，其机载成像子系统由两组千伏X射线管和平板探测器组成，可提供一对射线照片、用于图像引导设置的锥形束计算机断层扫描图像以及追踪照射的实时荧光监视。结果：对于360度O形环旋转，静态射束定位的均方根精度为0.1 mm。对于0.75 Hz、40 mm冲程，动态射束响应和定位精度为+/- 0.6 mm;对于2.0 Hz、8 mm冲程，动态射束响应和定位精度为+/- 0.4 mm。图像的质量是令人鼓舞的使用基于断层扫描的设置。透视图像足以监测和跟踪肺tumors.Conclusions：我们的新系统的关键功能和能力是非常有前途的精确的图像引导设置和跟踪和追求照射的移动目标。(c)2006年爱思唯尔公司
Purpose: To develop and evaluate a new four-dimensional image-guided radiotherapy system, which enables precise setup, real-time tumor tracking, and pursuit irradiation.Methods and Materials: The system has an innovative gimbaled X-ray head that enables small-angle (+/- 2.4 degrees) rotations (pan and tilt) along the two orthogonal gimbals. This design provides for both accurate beam positioning at the isocenter by actively compensating for mechanical distortion and quick pursuit of the target. The X-ray head is composed of an ultralight C-band linear accelerator and a multileaf collimator. The gimbaled X-ray head is mounted on a rigid O-ring structure with an on-board imaging subsystem composed of two sets of kilovoltage X-ray tubes and flat panel detectors, which provides a pair of radiographs, cone beam computed tomography images useful for image guided setup, and real-time fluoroscopic monitoring for pursuit irradiation.Results: The root mean square accuracy of the static beam positioning was 0.1 mm for 360 degrees of O-ring rotation. The dynamic beam response and positioning accuracy was +/- 0.6 mm for a 0.75 Hz, 40-mm stroke and +/- 0.4 mm for a 2.0 Hz, 8-mm stroke. The quality of the images was encouraging for using the tomography-based setup. Fluoroscopic images were sufficient for monitoring and tracking lung tumors.Conclusions: Key functions and capabilities of our new system are very promising for precise image-guided setup and for tracking and pursuit irradiation of a moving target. (c) 2006 Elsevier Inc.