Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers.
Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers.
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DOI：
10.1038/s41598-023-31111-y
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发表时间：
2023-03-21
影响因子：
4.6
通讯作者：
Barnes, Gareth R. R.
中科院分区：
文献类型：
--
作者：
Hillebrand, Arjan;Holmes, Niall;Sijsma, Ndedi;O'Neill, George C. C.;Tierney, Tim M. M.;Liberton, Niels;Stam, Anine H. H.;van Klink, Nicole;Stam, Cornelis J. J.;Bowtell, Richard;Brookes, Matthew J. J.;Barnes, Gareth R. R.
脑磁图和脑电图（MEG/EEG）是癫痫诊断和术前评估的重要技术。然而，在当前基于低温的MEG系统中，传感器偏离头皮，这限制了信噪比（SNR），从而限制了对来自诸如海马体的深层结构的活动的敏感性。这种影响在儿童身上被放大，因为成人尺寸的固定头盔系统通常太大。此外，使用固定头盔系统的发作记录是有问题的，因为有限的运动容限和/或后勤考虑。光泵磁力计（OPMs）可以直接放置在头皮上，从而提高SNR并在癫痫发作期间进行记录。我们旨在证明OPM在临床人群中的性能。7例具有挑战性癫痫病例的患者使用12通道OPM系统和306通道基于冷冻剂的全头部系统进行了MEG记录：3名成人具有已知的发作间期癫痫样放电（IED）的深源或弱源（低SNR），沿着3名局灶性癫痫儿童和1名频繁癫痫发作的成人。对两个系统记录的简易爆炸装置的一致性进行了评估。在1例患者中，OPM检测到SQUID系统未发现的IED，在2例患者中，两种系统均未发现IED。对于其他患者，OPM数据与低温系统的数据非常一致，注意到这些数据是在不同的会话中记录的，总体上具有可比的SNR和IED产量。重要的是，OPM的可穿戴性使得能够记录癫痫发作期间运动过度的患者的癫痫发作活动。所观察到的发作发作和症状与以前的视频和立体脑电图记录一致。相对经济实惠的技术，结合降低的运行和维护成本，意味着基于OPM的MEG可以比当前的MEG系统更广泛地使用，并且可能成为头皮EEG的经济实惠的替代方案，具有增加空间精度、降低对体积传导/场扩散的敏感性以及增加对深源的敏感性的潜在益处。因此，可穿戴MEG为癫痫提供了前所未有的机会，鉴于其对患者的友好性，我们设想它不仅用于癫痫患者的术前评估，还用于首次癫痫发作后的诊断。
Magneto- and electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG systems the sensors are offset from the scalp, which limits the signal-to-noise ratio (SNR) and thereby the sensitivity to activity from deep structures such as the hippocampus. This effect is amplified in children, for whom adult-sized fixed-helmet systems are typically too big. Moreover, ictal recordings with fixed-helmet systems are problematic because of limited movement tolerance and/or logistical considerations. Optically Pumped Magnetometers (OPMs) can be placed directly on the scalp, thereby improving SNR and enabling recordings during seizures. We aimed to demonstrate the performance of OPMs in a clinical population. Seven patients with challenging cases of epilepsy underwent MEG recordings using a 12-channel OPM-system and a 306-channel cryogen-based whole-head system: three adults with known deep or weak (low SNR) sources of interictal epileptiform discharges (IEDs), along with three children with focal epilepsy and one adult with frequent seizures. The consistency of the recorded IEDs across the two systems was assessed. In one patient the OPMs detected IEDs that were not found with the SQUID-system, and in two patients no IEDs were found with either system. For the other patients the OPM data were remarkably consistent with the data from the cryogenic system, noting that these were recorded in different sessions, with comparable SNRs and IED-yields overall. Importantly, the wearability of OPMs enabled the recording of seizure activity in a patient with hyperkinetic movements during the seizure. The observed ictal onset and semiology were in agreement with previous video- and stereo-EEG recordings. The relatively affordable technology, in combination with reduced running and maintenance costs, means that OPM-based MEG could be used more widely than current MEG systems, and may become an affordable alternative to scalp EEG, with the potential benefits of increased spatial accuracy, reduced sensitivity to volume conduction/field spread, and increased sensitivity to deep sources. Wearable MEG thus provides an unprecedented opportunity for epilepsy, and given its patient-friendliness, we envisage that it will not only be used for presurgical evaluation of epilepsy patients, but also for diagnosis after a first seizure.
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影响因子：
5.7
作者：
Borna A;Iivanainen J;Carter TR;McKay J;Taulu S;Stephen J;Schwindt PDD
通讯作者：
Schwindt PDD
影响因子：
3.7
作者：
Boto E;Bowtell R;Krüger P;Fromhold TM;Morris PG;Meyer SS;Barnes GR;Brookes MJ
通讯作者：
Brookes MJ
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
DOI：
10.1109/34.121791
发表时间：
1992-02-01
影响因子：
23.6
作者：
BESL, PJ;MCKAY, ND
通讯作者：
MCKAY, ND
影响因子：
4.1
作者：
Bekelis, Kimon;Desai, Atman;Roberts, David W.
通讯作者：
Roberts, David W.