Sleep characteristics as predictor variables of stress systems markers in insomnia disorder
Sleep characteristics as predictor variables of stress systems markers in insomnia disorder
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DOI：
10.1111/jsr.12259
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发表时间：
2015-06-01
影响因子：
4.4
通讯作者：
Haack, Monika
中科院分区：
文献类型：
--
作者：
Floam, Samantha;Simpson, Norah;Haack, Monika
这项研究调查了睡眠特征在多大程度上作为炎症、下丘脑-垂体-肾上腺和自主系统标志物的预测变量。根据《精神疾病诊断统计手册》第五版诊断为失眠症的 29 名参与者（年龄 25.3 +/- 1.6 岁，失眠持续时间 6.6 +/- 0.8 年）和 19 名健康对照睡眠者（年龄 25.4 +/- 1.4 岁）接受了为期 2 周的在家评估，在家中记录睡眠日记并佩戴活动记录仪，然后访问研究中心 测量血压并采集血液和尿液样本。对基于体动记录仪和日记的睡眠持续时间、入睡潜伏期、入睡后觉醒和睡眠碎片/夜间觉醒次数进行平均，并作为因变量输入回归分析中。计算自主神经（血压、去甲肾上腺素）、炎症（单核细胞计数、白细胞介素 6、C 反应蛋白）和下丘脑-垂体-肾上腺系统（皮质醇）的综合评分，并用作回归模型中的预测变量。与对照组相比，失眠个体的睡眠时间较短（P
This study investigates the extent to which sleep characteristics serve as predictor variables for inflammatory, hypothalamic-pituitary-adrenal and autonomic systems markers. Twenty-nine participants with a diagnosis of insomnia disorder based on the Diagnostic Statistical Manual of Mental Disorders, Fifth Edition (age 25.3 +/- 1.6years, insomnia duration 6.6 +/- 0.8years) and 19 healthy control sleepers (age 25.4 +/- 1.4years) underwent a 2-week at-home evaluation keeping a sleep diary and wearing an actigraph, followed by a visit to the Research Center to measure blood pressure, and collect blood and urine samples. The actigraphy- and diary-based variables of sleep duration, sleep-onset latency, wake after sleep onset and sleep fragmentation/number of night-time awakenings were averaged and entered as dependent variables in regression analyses. Composite scores were calculated for the autonomic (blood pressure, norepinephrine), inflammatory (monocyte counts, interleukin-6, C-reactive protein) and hypothalamic-pituitary-adrenal systems (cortisol), and used as predictor variables in regression models.Compared with controls, individuals with insomnia had a shorter sleep duration (P