Bioinformatic analysis of Toll-like receptor sequences and structures.
Bioinformatic analysis of Toll-like receptor sequences and structures.
复制标题
Toll 样受体序列和结构的生物信息分析。
DOI:
10.1007/978-1-59745-541-1_5
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发表时间:
2009
期刊:
影响因子:
--
通讯作者:
Monie TP
中科院分区:
文献类型:
--
作者:
Monie TP
Continual advancements in computing power and sophistication, coupled with rapid increases in protein sequence and structural information, have made bioinformatic tools an invaluable resource for the molecular and structural biologists. With the degree of sequence information continuing to expand at an almost exponential rate, it is essential that scientists today have a basic understanding of how to utilise, manipulate, and analyse this information for the benefit of their own experiments. In the context of Toll-interleukin-1 receptor (TIR) domain containing proteins, we describe here a series of the more common and user-friendly bioinformatic tools available as internet-based resources. These will enable the identification and alignment of protein sequences, the identification of functional motifs, the characterisation of protein secondary structure, the identification of protein structural folds and distantly homologous proteins, and the validation of the structural geometry of modelled protein structures.
影响因子:
14.9
作者:
Altschul, SF;Madden, TL;Lipman, DJ
通讯作者:
Lipman, DJ
影响因子:
5.6
作者:
ALTSCHUL, SF;GISH, W;LIPMAN, DJ
通讯作者:
LIPMAN, DJ