Non-coding RNA and pseudogenes in neurodegenerative diseases: "The (un)Usual Suspects".
Non-coding RNA and pseudogenes in neurodegenerative diseases: "The (un)Usual Suspects".
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DOI：
10.3389/fgene.2012.00231
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发表时间：
2012
影响因子：
3.7
通讯作者：
Ciccodicola A
中科院分区：
文献类型：
--
作者：
Costa V;Esposito R;Aprile M;Ciccodicola A
神经退行性疾病和癌症是严重威胁人类健康的疾病。神经元和癌细胞之间的显著差异掩盖了其发病机制中所涉及的过程。细胞周期、DNA修复和细胞分化的缺陷可以决定癌症的无限增殖，或者相反，损害神经元的可塑性，导致细胞死亡和神经变性。影响基因表达的调节网络的改变有助于人类疾病的发作，包括神经退行性疾病，并且非编码RNA-特别是microRNA（miRNAs）-的失调被认为具有显著影响。最近，竞争性内源性RNA（ceRNA）-作为海绵-已被确定在癌症中，表明一个新的和复杂的调控网络。鉴于神经退行性疾病和癌症共享改变的基因和途径，并考虑到miRNA在神经发生中的新兴作用，我们假设ceRNA可能与神经退行性疾病有关。在这里，我们提出，并计算预测，这种调节机制可能是共享的疾病。可以预见的是，类似的调节也发生在其他复杂疾病中，需要进一步的研究。
Neurodegenerative disorders and cancer are severe diseases threatening human health. The glaring differences between neurons and cancer cells mask the processes involved in their pathogenesis. Defects in cell cycle, DNA repair, and cell differentiation can determine unlimited proliferation in cancer, or conversely, compromise neuronal plasticity, leading to cell death and neurodegeneration. Alteration in regulatory networks affecting gene expression contribute to human diseases onset, including neurodegenerative disorders, and deregulation of non-coding RNAs – particularly microRNAs (miRNAs) – is supposed to have a significant impact. Recently, competitive endogenous RNAs (ceRNAs) – acting as sponges – have been identified in cancer, indicating a new and intricate regulatory network. Given that neurodegenerative disorders and cancer share altered genes and pathways, and considering the emerging role of miRNAs in neurogenesis, we hypothesize ceRNAs may be implicated in neurodegenerative diseases. Here we propose, and computationally predict, such regulatory mechanism may be shared between the diseases. It is predictable that similar regulation occurs in other complex diseases, and further investigation is needed.