Major depression in multiple sclerosis - A population-based perspective
Major depression in multiple sclerosis - A population-based perspective
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DOI：
10.1212/01.wnl.0000095964.34294.b4
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发表时间：
2003-12-09
期刊：
影响因子：
9.9
通讯作者：
Metz, LM
中科院分区：
文献类型：
--
作者：
Patten, SB;Beck, CA;Metz, LM
目的：在控制非特异性疾病影响的人群样本中，确定多发性硬化症（MS）中重度抑郁症的患病率。方法：本研究使用的数据来自加拿大进行的一项大规模全国性调查：加拿大社区健康调查（CCHS）。该分析包括115，071名在数据收集时年满18岁的CCHS受试者。CCHS访谈获得了自我报告的MS诊断，并采用了一个简短的抑郁症预测访谈：复合国际抑郁症诊断访谈简表。在患有和不患有MS以及患有和不患有其他长期医学疾病的受试者中估计12个月期间的重性抑郁症患病率。结果：MS患者的抑郁症患病率高于非MS患者和其他患者。在调整年龄和性别后，这种相关性仍然存在（调整后的比值比= 2.3，95%CI 1.6至3.3）。18至45岁年龄范围内MS的重度抑郁患病率高达25.7%（95%CI 15.6至35.7）。结论：MS人群中抑郁症的患病率升高。这种升高不是选择偏差的人为产物，并且超过了与具有一个或多个其他长期条件相关的升高。
Objective: To determine the prevalence of major depression in multiple sclerosis ( MS) in a population- based sample controlling for nonspecific illness effects. Methods: This study used data from a large- scale national survey conducted in Canada: the Canadian Community Health Survey ( CCHS). The analysis included 115,071 CCHS subjects who were 18 years or older at the time of data collection. The CCHS interview obtained self- reported diagnoses of MS and employed a brief predictive interview for major depression: the Composite International Diagnostic Interview Short Form for Major Depression. The 12- month period prevalence of major depression was estimated in subjects with and without MS and with and without other long- term medical conditions. Results: The prevalence of major depression was elevated in persons with MS relative to those without MS and those reporting other conditions. The association persisted after adjustment for age and sex ( adjusted odds ratio = 2.3, 95% CI 1.6 to 3.3). Major depression prevalence in MS for those in the 18- to 45- year age range was high at 25.7% ( 95% CI 15.6 to 35.7). Conclusions: The prevalence of major depression in the population with MS is elevated. This elevation is not an artifact of selection bias and exceeds that associated with having one or more other long- term conditions.