Therapeutic Applications of Extracellular Matrix.
Therapeutic Applications of Extracellular Matrix.
复制标题
细胞外基质的治疗应用。
DOI：
10.1089/wound.2015.0652
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发表时间：
2015
影响因子：
4.9
通讯作者：
Hocking,DeniseC
中科院分区：
文献类型：
--
作者：
Hocking,DeniseC
慢性和难以愈合的伤口是我们医疗保健系统的巨大负担，并损害了数百万人的生活质量。再生医学的一个新兴焦点是开发天然生物材料，其可以通过重建细胞外基质（ECM）中发现的蛋白质和多糖的功能和结构特性来刺激组织形成或修复。有前途的新发展包括制造新型ECM基生物制剂，以选择性地将药物或生长因子输送到伤口;新型生物活性组织密封剂，支架和水凝胶;以及来自脱细胞组织的诱导伤口敷料。在这个论坛问题上强调的进展提供了一个令人兴奋的一瞥，以ECM为基础的伤口治疗的增长潜力。
Chronic and hard-to-heal wounds are a tremendous burden on our healthcare system and impair the quality of life for millions of people. An emerging focus of regenerative medicine is the development of natural biomaterials that can stimulate tissue formation or repair by recreating the functional and structural properties of proteins and polysaccharides found within the extracellular matrix (ECM). Promising new developments include the fabrication of novel ECM-based biologics to selectively deliver drugs or growth factors to wounds; new classes of bioactive tissue sealants, scaffolds, and hydrogels; as well as inductive wound dressings derived from decellularized tissues. The advances highlighted in this forum issue provide an exciting glimpse into the growing potential of ECM-based wound therapeutics.