Normative references of heart rate variability and salivary alpha-amylase in a healthy young male population.
Normative references of heart rate variability and salivary alpha-amylase in a healthy young male population.
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DOI：
10.1186/1880-6805-31-9
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发表时间：
2012-04-20
影响因子：
3.1
通讯作者：
Miyazaki Y
中科院分区：
文献类型：
--
作者：
Kobayashi H;Park BJ;Miyazaki Y
本研究旨在提供健康年轻男性人群心率变异性和唾液α-淀粉酶的标准参考值，特别关注其分布和可重复性。研究了417名日本健康青年男性的短期心率变异性。此外，在430名男性中测量唾液α-淀粉酶。受试者的平均年龄为21.9岁，标准差为1.6岁。心率变异性指数和唾液α-淀粉酶水平的个体间差异绘制成直方图。数据表示为每个生理指标的平均值、中位数、标准差、变异系数、偏度、峰度以及第5和第95位数。平均记录值为心动周期945.85 ms，对数转换高频分量9.84 ln-ms 2，对数转换低频分量10.42 ln-ms 2，对数转换低频与高频比0.58 ln-ratio，搏动间隔的标准差为27.17 ms，连续差的均方根为37.49 ms，原始唾液α-唾液α-淀粉酶为17.48 U/mL，平方根唾液α-淀粉酶为3.96 sqrt[U/mL]，对数转换的唾液α-淀粉酶为2.65 ln[U/mL]。对数转换的心率变异性指数表现出几乎对称的分布;然而，心率变异性的时域指数（心跳间隔的标准差和连续差的均方根）表现出右偏（正偏）分布。观察到生唾液α-淀粉酶的显著右偏分布。对数转换改善唾液α-淀粉酶的分布，但平方根转换是不够的。使用组内相关系数评估这些指标的日常重现性。大多数心率变异性和唾液指数的组内相关系数约为0.5至0.6。原始唾液标志物的组内相关系数约为0.6，这与心率变异性相似;然而，唾液标志物的对数转换并没有显著提高其重现性。没有观察到心率变异性的交感神经指标与唾液α-淀粉酶之间的相关性。由于在这项研究中检查的样本人群涉及有限的年龄和性别变化，目前的结果是独立的这些因素，并表明纯粹的个体间变异。
This study aimed to present normative reference values of heart rate variability and salivary alpha-amylase in a healthy young male population with a particular focus on their distribution and reproducibility. The short-term heart rate variability of 417 young healthy Japanese men was studied. Furthermore, salivary alpha-amylase was measured in 430 men. The average age of the subjects were 21.9 years with standard deviation of 1.6 years. Interindividual variations in heart rate variability indices and salivary alpha-amylase levels were plotted as histograms. Data are presented as the mean, median, standard deviation, coefficient of variation, skewness, kurtosis, and fifth and 95th percentiles of each physiological index. Mean recorded values were heart period 945.85 ms, log-transformed high frequency component 9.84 ln-ms2, log-transformed low frequency component 10.42 ln-ms2, log-transformed low frequency to high frequency ratio 0.58 ln-ratio, standard deviation of beat-to-beat interval 27.17 ms and root mean square of successive difference 37.49 ms. The mean value of raw salivary alpha-amylase was 17.48 U/mL, square root salivary alpha-amylase 3.96 sqrt[U/mL] and log-transformed salivary alpha-amylase 2.65 ln[U/mL]. Log-transformed heart rate variability indices exhibited almost symmetrical distributions; however, time-domain indices of heart rate variability (standard deviation of beat-to-beat interval and root mean square of successive difference) exhibited right-skewed (positive skewness) distributions. A considerable right-skewed distribution was observed for raw salivary alpha-amylase. Logarithmic transformation improved the distribution of salivary alpha-amylase, although square root transformation was insufficient. The day-to-day reproducibility of these indices was assessed using intraclass correlation coefficients. Intraclass correlation coefficients of most heart rate variability and salivary indices were approximately 0.5 to 0.6. Intraclass correlation coefficients of raw salivary markers were approximately 0.6, which was similar to those of heart rate variability; however, log transformation of the salivary markers did not considerably improve their reproducibility. Correlations between sympathetic indicators of heart rate variability and salivary alpha-amylase were not observed. Because the sample population examined in this study involved limited age and gender variations, the present results were independent of these factors and were indicative of pure interindividual variation.
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DOI：
10.2114/jpa.15.87
发表时间：
1996-01-01
期刊：
Applied Human Science
影响因子：
--
作者：
Kobayashi, Hiromitsu
通讯作者：
Kobayashi, Hiromitsu
影响因子：
37.8
作者：
MONTANO, N;RUSCONE, TG;MALLIANI, A
通讯作者：
MALLIANI, A
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
影响因子：
--
作者：
Carrasco, S.;Gonzalez, R.;Yanez, O.
通讯作者：
Yanez, O.
影响因子：
3.1
作者：
Kobayashi, Hiromitsu
通讯作者：
Kobayashi, Hiromitsu