A Smart Photosensitizer-Cerium Oxide Nanoprobe for Highly Selective and Efficient Photodynamic Therapy
A Smart Photosensitizer-Cerium Oxide Nanoprobe for Highly Selective and Efficient Photodynamic Therapy
复制标题
用于高选择性和高效光动力治疗的智能光敏剂-氧化铈纳米探针
DOI：
10.1021/acs.inorgchem.9b00363
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发表时间：
2019-06-03
影响因子：
4.6
通讯作者：
Tang, Yu
中科院分区：
文献类型：
--
作者：
Fan, Yifan;Li, Pengyun;Tang, Yu
具有可逆表面Ce 3 +/Ce 4+氧化还原对的氧化铈（CeOx）在催化反应中发挥了重要作用，而CeOx的过氧化氢酶模拟物在生物治疗领域中很少引起注意。在此，智能光敏剂氧化铈纳米探针的开发，代表了一个有前途的范例，在高性能的光动力治疗。光敏剂通过基质金属蛋白酶-2（MMP-2）的底物肽（EGPLGVRGK）与CeOx纳米颗粒连接。当肽接头（EGPLGVRGK）被癌症生物标志物MMP-2切割时，智能纳米探针可以从到达癌细胞之前的沉默状态转换为细胞内的激活状态，以打开荧光和1 O2生成。CeOx作为一种优良的过氧化氢酶样化合物，能够分解内源性过氧化氢，缓解肿瘤组织缺氧。通过CeOx的常规应用，我们的研究创新性地展示了智能纳米探针如何缓解肿瘤缺氧并实现高选择性和高效个性化治疗的治疗效果。
Cerium oxide (CeOx) with a reversible surface Ce3+/Ce4+ redox pair has played an important role in catalytic reactions, whereas catalase mimetics of CeOx have attracted little attention in the field of biotherapy. Herein, a smart photosensitizercerium oxide nanoprobe was developed to represent a promising paradigm in high-performance photodynamic therapy. The photosensitizer was linked to CeOx nanoparticles through a substrate peptide (EGPLGVRGK) of matrix metalloproteinase-2 (MMP-2). The smart nanoprobe could be converted from the silent state before arriving at the cancer cells to the activated state within the cells to turn on the fluorescence and 1O2 generation when the peptide linker (EGPLGVRGK) was cut by the cancer biomarker MMP-2. Moreover, CeOx played the role of an excellent catalase-like compound to decompose endogenous hydrogen peroxide to relieve tumor hypoxia. Via the conventional application of CeOx, our study showed innovatively how a smart nanoprobe could relieve tumor hypoxia and achieve a therapeutic effect for highly selective and efficient personalized treatment.