Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging
Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging
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DOI：
10.1042/cs20120291
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发表时间：
2013-03-01
期刊：
影响因子：
6
通讯作者：
Seals, Douglas R.
中科院分区：
文献类型：
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作者：
DeVan, Allison E.;Eskurza, Iratxe;Seals, Douglas R.
在本研究中，我们检验了IFG（空腹血糖受损）会加剧年龄相关性血管内皮功能障碍以及定期有氧运动可以预防这种影响的假设。数据分析来自一个队列的131名不吸烟的男性和女性没有明显的临床疾病。与年轻成人对照组（年龄= 24 +/- 1岁，n = 29;数值为平均值+/- S.E.M.）相比，肱动脉FMD（流量介导的扩张），测量管道动脉EDD（内皮依赖性舒张），降低33%[7.93 +/- 0.33对5.27 +/- 0.37%Delta（%变化），P < 0.05]，MA/O（中年/老年）NFG成人（空腹血糖正常）（45分钟/天，>= 5天/周，62 +/- 1岁，n = 23）与他们的非运动同龄人相比，仅略低于年轻对照组（P < 0.05）。最重要的是，患有IFG的MA/O成人患者在定期进行有氧运动后FMD完全保留（6.99 +/- 0.69%Delta，65 +/- 1岁，n = 16）。在合并样本中，空腹血糖与FMD呈负相关（r =-0.42，P < 0.01），并且是FMD最强的独立预测因素（R-2=0.32）。FMD的组间差异不受其他受试者特征或肱动脉特性的影响，包括肱动脉扩张至舌下NTG（硝酸甘油，即非内皮依赖性扩张）。IFG会加重与年龄相关的血管内皮功能障碍，这种不良反应在定期进行有氧运动的MA/O成人中完全可以预防。
In the present study, we tested the hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and that regular aerobic exercise prevents this effect. Data were analysed from a cohort of 131 non-smoking men and women without overt clinical disease. Compared with young adult controls (age = 24 +/- 1 years, n = 29; values are means +/- S.E.M.), brachial artery FMD (flow-mediated dilation), a measure of conduit artery EDD (endothelium-dependent dilation), was 33% lower [7.93 +/- 0.33 against 5.27 +/- 0.37%Delta (% change), P < 0.05] in MA/O (middle-aged/older) adults with NFG (normal fasting plasma glucose) (45 min/day for >= 5 days/week, 62 +/- 1 years, n = 23) compared with their non-exercising peers and only slightly less than young controls (P < 0.05). Most importantly, FMD was completely preserved in MA/O adults with IFG who regularly performed aerobic exercise (6.99 +/- 0.69%Delta, 65 +/- 1 years, n = 16). In the pooled sample, fasting plasma glucose was inversely related to FMD (r = -0.42, P < 0.01) and was the strongest independent predictor of FMD (R-2=0.32). Group differences in FMD were not affected by other subject characteristics or brachial artery properties, including brachial artery dilation to sublingual NTG (nitroglycerine, i.e. endothelium-independent dilation). IFG exacerbates age-associated vascular endothelial dysfunction and this adverse effect is completely prevented in MA/O adults who regularly perform aerobic exercise.