Aggressive progression of breast cancer with microscopic pulmonary emboli possessing a stem cell-like phenotype independent of its origin
Aggressive progression of breast cancer with microscopic pulmonary emboli possessing a stem cell-like phenotype independent of its origin
复制标题
DOI：
10.1111/j.1440-1827.2009.02502.x
复制
发表时间：
2010-03-01
影响因子：
2.2
通讯作者：
Iwashita, Toshihide
中科院分区：
文献类型：
--
作者：
Kawasaki, Hideya;Ogura, Hiroyuki;Iwashita, Toshihide
显微镜下肺肿瘤栓塞很难诊断。在此提出的情况下，病人谁患有急性呼吸困难和乳腺癌的右侧。乳腺癌诊断后两周，患者开始出现呼吸困难。在呼吸困难2周后，患者在没有准确诊断呼吸困难的情况下死亡。尸检显示乳腺癌有大量显微镜下的肺栓塞。免疫组织化学显示，原发部位的大多数癌细胞对雌激素受体、孕激素受体Her 2/neu癌基因（三阴性）和干细胞样标志物（OCT 3/4、NANOG 2、CD 44、CD 24、醛脱氢酶1（ALDH 1））均呈阴性。然而，肺（转移部位）中的乳腺癌细胞为三阴性，但富含干细胞样标志物（OCT 3/4+、NANOG 2+、CD 44 +/CD 24-/低、ALDH 1+）。这是一个重要的病例报告，表明血管栓塞本身含有独立于起源的“干性”的基本分子特征。
Microscopic pulmonary tumor embolism is difficult to diagnose. Herein is presented the case of a patient who suffered from acute dyspnea and breast cancer on the right side. Two weeks after the breast cancer diagnosis the patient began to experience dyspnea. After 2 weeks of dyspnea, the patient died without an accurate diagnosis of dyspnea. Autopsy indicated massive microscopic pulmonary emboli of the breast cancer. Immunohistochemistry showed that most of the cancer cells in the primary site were negative for estrogen receptors, progesterone receptors Her2/neu oncogene (triple negative), and stem cell-like markers (OCT3/4, NANOG2, CD44, CD24, aldehyde dehydrogenase 1 (ALDH1)). The breast cancer cells in the lung (the metastasized site), however, were triple negative, but were enriched in stem cell-like markers (OCT3/4+, NANOG2+, CD44+/CD24-/low, ALDH1+). This is a significant case report indicating that vascular emboli themselves contain the essential molecular signature of 'stemness' independent of the origin.