COMPARISON OF IVERMECTIN AND DIETHYLCARBAMAZINE IN THE TREATMENT OF ONCHOCERCIASIS
COMPARISON OF IVERMECTIN AND DIETHYLCARBAMAZINE IN THE TREATMENT OF ONCHOCERCIASIS
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DOI：
10.1056/nejm198507183130301
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
WILLIAMS, PN
中科院分区：
文献类型：
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作者：
GREENE, BM;TAYLOR, HR;WILLIAMS, PN
在一项双盲、安慰剂对照试验中，将伊维菌素与乙胺嗪治疗盘尾丝虫病进行了比较。将患有中度至重度感染和眼部受累的男性（30名）随机分配接受单次口服剂量的伊维菌素（200 μ g/kg体重）、每日一次的乙胺嗪，持续8天，或安慰剂。乙胺嗪引起的全身反应明显比伊维菌素严重（P < 0.001），而伊维菌素的反应与安慰剂的反应没有差异。在治疗的第1周，乙胺嗪显著增加眼内点状混浊的数量（P < 0.001），以及角膜内死亡和存活的微丝蚴的数量。伊维菌素无此作用。伊维菌素和乙胺嗪均能迅速降低皮肤微丝蚴计数，但只有伊维菌素组在6个月结束时仍显著低于安慰剂组（P < 0.005）。观察力从结节分离的蠕虫分析获得2个月。在治疗开始后，两种药物对生存力都没有影响。伊维菌素似乎是一种耐受性更好，更安全和更有效的杀微丝蚴剂比乙胺嗪治疗盘尾丝虫病。
Ivermectin was compared with diethylcarbamazine for the treatment of onchocerciasis in a double-blind, placebo-controlled trial. Men (30) with moderate to heavy infection and ocular involvement were randomly assigned to receive ivermectin in a single oral dose (200 .mu.g/kg of body wt), diethylcarbamazine daily for 8 days, or placebo. Diethylcarbamazine caused a significantly more severe systemic reaction than ivermectin (P < 0.001), whereas the reaction to ivermectin did not differ from the reaction to placebo. Diethylcarbamazine markedly increased the number of punctate opacities in the eye (P < 0.001), as well as the number of dead and living microfilariae in the cornea over the 1st wk of therapy. Ivermectin had no such effect. Both ivermectin and diethylcarbamazine promptly reduced skin microfilaria counts, but only in the ivermectin group did counts remain significantly lower (P < 0.005) than in the placebo group at the end of 6 mo. of observation. Analysis of adult worms isolated from nodules obtained 2 mo. after the start of therapy showed no effect of either drug on viability. Ivermectin appears to be a better tolerated, safer and more effective microfilaricidal agent than diethylcarbamazine for the treatment of onchocerciasis.