Role of acquired immune deficiency syndrome-defining conditions in human immunodeficiency virus-associated wasting.
Role of acquired immune deficiency syndrome-defining conditions in human immunodeficiency virus-associated wasting.
复制标题
获得性免疫缺陷综合征定义条件在人类免疫缺陷病毒相关消瘦中的作用。
DOI：
10.1086/375894
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Gorbach,SL
中科院分区：
文献类型：
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作者：
Wanke,CA;Silva,M;Ganda,A;Fauntleroy,J;Spiegelman,D;Knox,TA;Gorbach,SL
为了评估获得性免疫缺陷综合征定义条件（adc）在人类免疫缺陷病毒（HIV）相关消瘦中的作用，我们分析了一项营养和HIV队列研究中671名参与者的纵向数据。在基线和6个月的研究访问期间收集adc、身高和体重数据。ADC的发生频率随着时间的推移而降低，但消瘦的相对风险（体重指数[BMI]下降至<20 kg/m2）随着bbb1 ADC的发生而增加；每增加一个历史ADC，浪费的RR增加1.3倍。在研究访问前6个月的任何ADC与BMI下降至<20 kg/m2相关。每增加一个最近的ADC，消瘦的风险增加2.7倍。当调整社会经济地位、CD4细胞计数、能量摄入或基线BMI时，这些风险没有改变。虽然adc促进了消耗的发展，但它们的贡献相对较小。
To evaluate the contribution of acquired immune deficiency syndrome–defining conditions (ADCs) in human immunodeficiency virus (HIV)–associated wasting, we analyzed longitudinal data from 671 participants in a nutrition and HIV cohort study. Data on ADCs, height, and weight were collected at baseline and during 6 monthly study visits. The frequency of ADCs decreased over time, but the relative risk (RR) of wasting (decrease in body mass index [BMI] to <20 kg/m2) increased with a history of >1 ADC; the RR of wasting increased 1.3-fold with each additional historical ADC. Any ADC during the 6 months prior to a study visit was associated with a decrease in BMI to <20 kg/m2. The risk of wasting increased 2.7-fold with each additional recent ADC. These risks were not altered when adjusted for socioeconomic status, CD4 cell count, energy intake, or baseline BMI. Although ADCs contribute to the development of wasting, their contribution is relatively small.