The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age
The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age
复制标题
DOI：
10.1111/sji.12193
复制
发表时间：
2014-10-01
影响因子：
3.7
通讯作者：
Kozak, T.
中科院分区：
文献类型：
--
作者：
Novak, J.;Dobrovolny, J.;Kozak, T.
粘膜相关不变T（MAIT）细胞是先天性T细胞，其占人类外周血T细胞的10%。在个体发育过程中，MAIT细胞首先可以在脐带血中检测到少量，但出生后稳步上升。在这项基于人群的研究中，我们发现他们的数量继续增加，在第三和第四个十年达到最高水平（4.5%的CD 3（+）细胞，65个细胞/升）。在这个年龄，MAIT细胞的数量表现出最高的个体间变异性。然后数值急剧下降; 80岁及以上受试者的MAIT细胞平均比育龄受试者少10倍，无论是绝对值还是占CD 3（+）T细胞的百分比。MAIT细胞的衰老与降低的CD 8/双阴性（DN）比率相关。最后，我们观察到生育年龄女性的MAIT细胞数量明显高于同龄男性。我们的数据表明，旨在阐明MAIT细胞在人类病理学中的作用的进一步研究必须招募年龄和性别匹配的对照。
Mucosal-associated invariant T (MAIT) cells are innate-like T cells comprising up to 10% of the peripheral blood T cells in humans. During ontogeny, MAIT cells can first be detected in the cord blood in low amounts, but rise steadily after birth. In this population-based study, we show that their counts continue to increase, reaching maximal levels (4.5% of CD3(+) cells, 65cells/l) in the third and fourth decenniums. At this age, the amounts of MAIT cells exhibit the highest interindividual variability. The values then dramatically decline; subjects 80years old and older have on average 10 times less MAIT cells, both absolutely and as a percentage among CD3(+) T cells, than subjects in fertile age. The senescence of MAIT cells is associated with decreased CD8/double negative (DN) ratio. Finally, we observed significantly higher amounts of MAIT cells in women of reproductive age than in men of the same age. Our data suggest that further studies aimed at elucidating a role of MAIT cells in human pathologies must recruit age- and gender-matched controls.