Designing Bioinspired 2D MoSe2 Nanosheet for Efficient Photothermal-Triggered Cancer Immunotherapy with Reprogramming Tumor-Associated Macrophages
Designing Bioinspired 2D MoSe2 Nanosheet for Efficient Photothermal-Triggered Cancer Immunotherapy with Reprogramming Tumor-Associated Macrophages
复制标题
设计仿生二维 MoSe2 纳米片，通过重编程肿瘤相关巨噬细胞进行高效光热触发癌症免疫治疗
DOI：
10.1002/adfm.201901240
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发表时间：
2019-07-01
影响因子：
19
通讯作者：
Chen, Tianfeng
中科院分区：
文献类型：
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作者：
He, Lizhen;Nie, Tianqi;Chen, Tianfeng
在基于纳米药物的癌症治疗中，纳米材料在循环中的非特异性吸收和清除是治疗失败的主要原因。因此，本文利用仿生红细胞膜来伪装具有高光热转换效率的二维MoSe2纳米片，以防止巨噬细胞吞噬，从而提高血液相容性和循环时间。红细胞MoSe2增强的光热疗法(PTT)在体内表现出强大的抗肿瘤效果，它可以触发肿瘤相关抗原的释放，激活细胞毒性T淋巴细胞，并使PD-1/PD-L1途径失活，从而避免免疫逃逸。此外，在消融的肿瘤微环境中，肿瘤相关巨噬细胞被有效地重新编程为杀瘤M1表型，以增强抗肿瘤作用。综上所述，这种仿生功能化因此为临床翻译的个性化PTT触发免疫疗法提供了实质性的进步。
Nonspecific absorption and clearance of nanomaterials during circulation is the major cause for treatment failure in nanomedicine-based cancer therapy. Therefore, herein bioinspired red blood cell (RBC) membrane is employed to camouflage 2D MoSe2 nanosheets with high photothermal conversion efficiency to achieve enhanced hemocompatibility and circulation time by preventing macrophage phagocytosis. RBC MoSe2-potentiated photothermal therapy (PTT) demonstrates potent in vivo antitumor efficacy, which triggers the release of tumor-associated antigens to activate cytotoxic T lymphocytes and inactivate the PD-1/PD-L1 pathway to avoid immunologic escape. Furthermore, in the ablated tumor microenvironment, the tumor-associated macrophages are effectively reprogrammed to tumoricidal M1 phenotype to potentiate the antitumor action. Taken together, this biomimetic functionalization thus provides a substantial advance in personalized PTT-triggered immunotherapy for clinical translation.