Modulation of drug transporters at the blood-brain barrier
Modulation of drug transporters at the blood-brain barrier
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DOI：
10.1159/000075545
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发表时间：
2004-01-01
期刊：
影响因子：
3.1
通讯作者：
Miller, DS
中科院分区：
文献类型：
--
作者：
Fricker, G;Miller, DS
治疗中枢神经系统疾病的一个主要挑战是药物对大脑的渗透有限。负责的结构是大脑的毛细血管，其内皮细胞形成所谓的血脑屏障。了解细胞和分子结构以及这一屏障的综合功能是成功将药物输送到大脑的先决条件。在这里，我们简要回顾了目前关于活性转运蛋白（ABC和有机阴离子转运蛋白）在血脑屏障中起作用的知识。我们描述了以下新方法：(1)调节载体蛋白功能；(2)通过靶向位点特异性药物递送系统（如免疫脂质体和纳米颗粒系统）绕过基于转运蛋白的载体。版权所有(C) 2004 S. Karger AG，巴塞尔。
A major challenge in the management of diseases of the central nervous system is the limited penetration of drugs into the brain. The structures responsible are the capillaries of the brain, whose endothelial cells form the so-called blood-brain barrier. Understanding the cellular and molecular structure as well as integrated function of this barrier is a prerequisite for successful drug delivery to the brain. Here we briefly review current knowledge about the active transport proteins (ABC and organic anion transporters) which function at the blood-brain barrier. We describe novel approaches to (1) modulate carrier protein function, and (2) circumvent the transporter-based carrier by targeted site-specific drug delivery systems, such as immunoliposome and nanoparticulate systems. Copyright (C) 2004 S. Karger AG, Basel.