Protriptyline in the treatment of sleep apnoea.
Protriptyline in the treatment of sleep apnoea.
复制标题
普罗替林治疗睡眠呼吸暂停。
作者：
William A. Conway;F. Zorick;P. Piccione;T. Roth
9例阻塞性睡眠呼吸暂停患者每晚给予5 ~ 20 mg普罗替林治疗2 ~ 18个月。在四名患者中，症状和测量的睡眠质量以及呼吸暂停频率和持续时间有显著的持续改善。两名患者没有改善，三名患者出现无法忍受的副作用，无法进行适当的治疗。呼吸暂停频率是反应性的唯一明显预测因素。每小时呼吸暂停发作少于30次的患者持续改善。每小时发作超过60次的四名患者中只有两名得到改善。这些结果提供了额外的证据表明，一个仔细监测的普罗替林试验可能有利于选定的轻至中度阻塞性睡眠呼吸暂停患者。
Nine patients with obstructive sleep apnoea were treated with 5 to 20 mg of protriptyline each night for two to 18 months. In four patients, there was dramatic, sustained improvement in symptoms and measured sleep quality and apnoea frequency and duration. There was no improvement in two patients and three developed intolerable side-effects preventing adequate treatment. Apnoea frequency was the only apparent predictor of responsiveness. Those with fewer than 30 episodes of apnoea per hour consistently improved. Only two of four patients with more than 60 episodes per hour improved. These results provide additional evidence that a carefully monitored trial of protriptyline may benefit selected patients with mild to moderate obstructive sleep apnoea.